油茶皂苷对高脂血症大鼠血管内皮细胞的保护作用

目的研究油茶皂苷(SQS)对高脂血症大鼠血管内皮细胞的保护作用。方法 60只SD大鼠,随机分为SQS高、中、低剂量组、氯贝丁酯组、高脂模型组和正常组,建立大鼠高脂血症模型。连续给药14 d后检测大鼠血清血脂、氧化亚氮(NO)、氧化亚氮合酶(NOS)、血管内皮素(ET)、可溶性细胞间黏附分子(ICAM-1)和可溶性血管细胞黏附分子(VCAM-1)水平。结果与高脂模型组比较,SQS可降低高脂血症大鼠血清三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、ICAM-1、VCAM-1、ET,升高NO、cNOS,有效维持NO/ET平衡,对HDL-C、iNOS影响不明显。结论 SQS能调整脂质代谢,抑制炎症反应,并能改善高脂血症大鼠血管内皮细胞功能。

Protective effect of sasanquasaponin ( SQS ) on endothelial cells in experimental hyperlipidemic rats

Objective To determine the protective effects of sasanquasaponin(SQS) on endothelial cells in the experimental hyperlipidemic rats.Methods Sixty SD rats were randomly divided into six groups,including SQS-treated group(high dosage,medium dosage and low dosage),Clofibrate-treated group,fatty liver model group,normal control group.The level of serum lipid,nitric oxide(NO),nitric oxidesynthase(NOS),endothelin(ET),ICAM-1 and VCAM-1 were measured.Results In comparing with normal control group,serum TC,TG,LDL-C were significantly decreased,but serum HDL-C was increased.In the successful formation of hyperlipidemia model.In comparing with fatty liver model group,serum TC,TG,LDL-C,ICAM-1,VCAM-1,ET were significantly decreased,The level of NO,cNOS were significantly increased and NO/ET was keep balance.At the same time,the level of HDL-C,iNOS was not increase.Conclusion The results indicate that SQS can modulate lipid metabolism,inhibit Inflammatory response,keep the balance of NO/ET thus might protect vascular endothelial cells.