Fetal sensitization to cow''s milk protein and wheat: cow''s milk protein and wheat-specific TNF-α production by umbilical cord blood cells and subsequent decline of TNF-α production by peripheral blood mononuclear cells following dietary intervention |
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Authors: | Carla M. Ward Lee Geng Harumi Jyonouchi |
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Affiliation: | Division of Allergy and Immunology, Department of Pediatrics, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA. |
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Abstract: | We present a case of fetal sensitization to cow's milk protein (CMP) and wheat, resulting in non-IgE mediated food allergy (NFA). Fetal sensitization was indicated by onset of NFA symptoms shortly after birth and CMP/wheat-specific tumor necrosis factor-alpha (TNF-alpha) production by cord blood mononuclear cells. Following dietary intervention, we observed a decline of TNF-alpha production by peripheral blood mononuclear cells with stimuli of these dietary proteins (DPs) but recurrence of reactivity was observed following viral gastroenteritis, while interleukin-10 production with these DPs persisted during his first 5 yr of life. This finding may indicate active suppressive mechanisms for maintaining oral tolerance. |
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Keywords: | fetal sensitization interleukin-10 non-IgE mediated food allergy oral tolerance tumor necrosis factor-α |
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