血浆可溶性CD36与2型糖尿病及亚临床大血管病变的关系 |
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引用本文: | 陈蕊华,蒋晓真,周龙珠,顾哲,顾佩莉,周斌,朱震宏,徐凌燕,邹宇峰.血浆可溶性CD36与2型糖尿病及亚临床大血管病变的关系[J].临床内科杂志,2013(12):809-811. |
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作者姓名: | 陈蕊华 蒋晓真 周龙珠 顾哲 顾佩莉 周斌 朱震宏 徐凌燕 邹宇峰 |
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作者单位: | [1]上海市浦东新区人民医院内分泌科,201299 [2]上海市浦东新区人民医院防保科,201299 |
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基金项目: | 上海市卫生局科研课题项目(2009214);上海市卫生局青年科研项目(2010Y047);上海市浦东新区优秀青年人才培养计划(PWRq2012-09);上海市浦东新区卫生局青年科研项目(PW2010B-6) |
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摘 要: | 目的 比较糖耐量正常人群、2型糖尿病及亚临床大血管病变患者血浆可溶性CD36(sCD36)的水平.方法 收集2型糖尿病患者196例及社区糖耐量正常人群135例,根据颈动脉超声分为糖尿病合并亚临床大血管病变组(SMDM组,118例)、单纯糖尿病组(DM组,78例)、亚临床大血管病变组(SMD组,42例)和对照组(NC组,93例),比较4组sCD36水平及其他临床和理化参数.结果 SM组、DM组及SMDM组的sCD36水平显著高于NC组(P<0.05),糖尿病与亚临床大血管病变对sCD36水平有正交互作用(F =5.741,P<0.05).Logistic回归显示,血浆sCD36是单纯亚临床大血管病变(OR =2.444,95% CI:1.449 ~4.125,P=0.001)及糖尿病患者合并亚临床大血管病变(OR=1.248,95% CI:1.038~1.499,P=0.018)和发生2型糖尿病的危险因素(OR=1.206,95% CI:1.026~1.418,P=0.024).结论 血浆sCD36水平可能是2型糖尿病与亚临床大血管病变的风险标志物.
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关 键 词: | 糖尿病 2型 亚临床大血管病变 可溶性CD36 |
Association of soluble CD36 with type 2 diabetes mellitus and subclinical macrovascular disease |
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Institution: | CHEN Ruihua,JIANG Xiaozhen, ZHOU Longzhu, et al. Department of Endocrinology, Pudong New Area People Hospital ,Shanghai 201299, China |
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Abstract: | Objective To compare the levels of plasma soluble CD36 in individuals with normal glucose tolerance,type 2 diabetes,and subclinical macrovascular disease. Methods According to results of B mode ultrasound,196 cases of type 2 diabetic patients and 135 individuals with normal glucose tolerance were divided into diabetes with subclinical macrovascular diseases ( SMDM, n = 118 ), diabetic group ( DM, n = 78 ), subclinical macrovascular diseases( SMD, n = 42) and normal control group( NC, n = 93 ). Levels of sCD36 and other clinical characteristics were compared among four groups. Results Plasma sCD3s was high- er in SMD group,DM group and SMDM group than in control group(P 〈0.05). There were positive interac- tions between type 2 diabetes and subclinical macrovascular disease on levels of sCD36 (F = 5. 741, P 〈0.05). Plasma sCD36 was risk predictor of subclinical macrovascular disease (OR = 2. 444,95% CI 1. 449-4. 125 ,P = 0. 001 ), diabetic patients with subclinical macrovascular disease ( OR = 1. 248,95% CI 1. 038-1. 499, P = 0.018 ) and type 2 diabetes ( OR = 1. 206,95 % CI 1. 026-1.418, P = 0.024 ). Conclusion P]asma sCD36 may be a risk marker of both type 2 diabetes and subclinical macrovascular disease. |
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Keywords: | Diabetes mellitus type 2 Subclinical macrovascular disease Soluble CD36 |
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