| 阻塞性睡眠呼吸暂停的遗传学研究 |
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| 引用本文： | 张希龙,殷凯生. 阻塞性睡眠呼吸暂停的遗传学研究[J]. 国际遗传学杂志, 2006, 29(2): 152-154. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| 作者姓名： | 张希龙 殷凯生 |
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| 作者单位： | 210029,南京医科大学第一附属医院呼吸科;210029,南京医科大学第一附属医院呼吸科 |
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| 摘 要： | 阻塞性睡眠呼吸暂停（obstructive sleep apnea, OSA）的遗传学研究尚处在初期，但迄今研究提示OSA有很强的遗传背景，其发病存在着家族聚集性且与相关中间表型有关，如与颅面结构、体内脂肪分布和呼吸调控的异常等有关。目前认为OSA的发病很可能是多基因与环境因素交互作用的结果。对OSA的分子遗传学研究可帮助理解OSA的病因和发病机理，并能促进对OSA的基因诊断和预防。
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| 关 键 词： | 阻塞性睡眠呼吸暂停 家族聚集性 中间表型 基因 |
| 收稿时间： | 2004-11-26 |
| 修稿时间： | 2004-11-26 |
Genetic Research of Obstructive Sleep Apnea |
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| ZHANG Xi-long,YIN Kai-sheng. Genetic Research of Obstructive Sleep Apnea[J]. International JOurnal of Genetics, 2006, 29(2): 152-154. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| Authors: | ZHANG Xi-long YIN Kai-sheng |
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| Affiliation: | Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China |
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| Abstract: | Genetic studies of obstructive sleep apnea(OSA) are in their infancy.The research so far has indicated a strong genetic background of OSA with an incidence of familial aggregation and OSA-associated intermediate phenotypes,such as abnormalities of craniofacial structure,body fat distribution and respiratory control and so on.It is currently regarded that occurrence of OSA may be a result of interactions between multigene and environmental factors.The molecular genetic research on OSA can assist us in understanding the pathogenesis of OSA and promote genetic diagnosis and prevention of OSA. |
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| Keywords: | Obstructive sleep apnea Familial aggregation Intermediate phenotype Gene |
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