S-腺苷蛋氨酸治疗慢性重型肝炎临床观察

目的:评价S-腺苷蛋氨酸在慢性重型肝炎中的治疗作用。方法:230例慢性乙型重型肝炎患者随机分为S-腺苷蛋氨酸治疗组和对照组,对照组给予护肝、静脉滴注门冬氨酸钾镁、间断应用白蛋白、新鲜血浆输注及对症支持治疗。S-腺苷蛋氨酸组在以上常规综合治疗的基础上,将1.0g S-腺苷蛋氨酸溶于5%葡萄糖溶液250ml,静脉滴注,每日1次。两组患者总疗程均为4周。观察两组患者治疗前、后的临床症状、体征,检测血清转氨酶、胆红素、白蛋白、碱性磷酸酶等生化指标。结果:S-腺苷蛋氨酸组患者临床症状、体征的缓解,血清生化指标如转氨酶、胆红素、碱性磷酸酶的下降均较对照组显著(P<0.05)。S-腺苷蛋氨酸组总有效率为80.50%,显著高于对照组(69.64%,P<0.05)。结论:S-腺苷蛋氨酸治疗重型肝炎在肝功能的改善、黄疸的消退上具有较好的疗效。

Clinical Observation of S-adenosylmethionine in Treatment of Chronic Severe Hepatitis

Objective:To evaluate the therapeutic effect of S-adenosylmethionine (SAMe) for chronic severe hepatitis. Methods: Two hundred and thirty cases with chronic severe hepatitis were divided into 2 groups randomly: control group and SAMe Group. Control group received routine treatment only. Patients in SAMe group received SAMe treatment 1.0 g 5% Glucose 250 ml intravenously per day for 4 weeks on the basis of routine therapy. The clinical symptoms, signs, serum aminotransferase, serum bilirubin, globulin, alkaline phosphatase were observed before and after treatment in both groups. Results: The improvement of clinical symptoms and signs, serum biochemical parameters such as aminotransferase, bilirubin, alkaline phosphatase in SAMe group were more significant than those in SAMe group (P< 0.05 ). The total response rate ( 85.0% ) in SAMe group was significantly higher than that of in the control group ( 69.64% )(P< 0.05 ). Conclusion: SAMe can improve hepatic function and resolve jaundice effectively in treatment of patients with severe hepatitis.