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| 口服顺铂微晶在小鼠体内的分布研究 | |
| 引用本文： | 刘丽娟,崔唏,金俊刚,王慧才. 口服顺铂微晶在小鼠体内的分布研究[J]. 山东大学学报(医学版), 2001, 39(1): 75-76 |
| 作者姓名： | 刘丽娟 崔唏 金俊刚 王慧才 |
| 作者单位： | 1. 山东大学药学院无机化学教研室 2. 山东大学公共卫生学院卫生化学教研室 3. 江苏省苏州安康医院 4. 山东大学药学院有机化学教研室 |
| 摘 要： | 目的研究顺铂微晶口服后在小鼠体内的吸收分布和消除情况。方法采用石墨炉原子吸收分光光度法，测定顺铂灌胃后在小鼠血液及不同脏器组织中的铂含量。结果顺铂在小鼠血液、肝、胃、肾组织中均有分布，胃组织中顺铂的吸收更为明显，肾组织中顺铂有明显的积蓄。结论顺铂微晶口服可以在胃组织中维持较高药浓，对治疗胃癌有进一步研究的意义，但其肾毒性不容忽视。 |
| 关 键 词： | 顺铂；药物评价；小鼠 |
| 文章编号： | 1000-0496(2001)01-0075-02 |
| 修稿时间： | 2000-04-27 |
THE STUDY ON THE MICROCRYSTALLINE CISPLATIN DISTRIBUTION IN MICE AFTER ORALL ADMINISTRATION |
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| LIU Li juan,CUI Xi,JIN Jun gang,et al. THE STUDY ON THE MICROCRYSTALLINE CISPLATIN DISTRIBUTION IN MICE AFTER ORALL ADMINISTRATION[J]. Journal of Shandong University:Health Sciences, 2001, 39(1): 75-76 | |
| Authors: | LIU Li juan CUI Xi JIN Jun gang et al |
| Abstract: | Objective:The absorbtion,distribution and elimination of microcrystalline cisplatin in mice by oral were studied. Methods:The levels of cisplatin in mice blood,liver,stomach and kidney were determined by Graphite Furnace Atomic Spectrophotometry after the administration of microcrystalline cisplatin.Results:The obvious distribution have been found in blood,liver,stomach and kidney,especially in stomach.The cisplatin could be stored up in kidney.Conclusion:The finding indicates that cisplatin may be adequate to treat stomach cancer orally,while its toxication on kidney should not be neglected. |
| Keywords: | Cisplatin Drug evaluation Mice |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |