Distribution of CD45RA and CD45RO T-lymphocyte subsets in rheumatoid arthritis synovial tissue |
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Authors: | Alisa E. Koch Philip G. Robinson James A. Radosevich Richard M. Pope |
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Affiliation: | (1) Department of Medicine, Northwestern Medical School and Veterans Administration Lakeside Medical Center, 60611 Chicago, Illinois;(2) Department of Pathology, Northwestern Medical School and Veterans Administration Lakeside Medical Center, 60611 Chicago, Illinois;(3) Northwestern University Medical School, 303 East Chicago Avenue, Ward 2-250, 60611 Chicago, Illinois |
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Abstract: | We have characterized the lymphocytes in the synovium of patients with rheumatoid arthritis (RA) by immunohistochemistry using monoclonal antibodies directed against B lymphocytes, T lymphocytes, and antibodies directed against CD45RA and CD45RO, which define T-cell subsets. Both CD45RA+ and CD45RO+ T lymphocytes were detected in the perivascular regions. CD45RA+ lymphocytes were present primarily in perivascular areas of moderate to large lymphocytic infiltration. Some synovial perivascular lymphocytic aggregates were organized into focal areas of CD45RA+ B lymphocytes surrounded by CD45RO+ T lymphocytes. In areas of diffuse lymphocytic infiltration, the T lymphocytes were CD45RO+. These data suggest that both CD45RO+ and CD45RA+ T lymphocytes enter the RA synovial tissue via the synovial vasculature and that, once in the tissue, the CD45RA+ T lymphocytes may undergo activation/maturation and acquire the CD45RO phenotype. |
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Keywords: | Lymphocytes subsets monoclonal antibodies immunohistochemistry |
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