Effect of Cassia nomame on Small Intestine Movement, Diuresis, and Anti-inflammation in Rats |
| |
Authors: | WANG Dan WANG Wei-ning QI Bao-chan ZHANG Qiu-hua SUN Gui-yuan |
| |
Affiliation: | WANG Dan;WANG Wei-ning;QI Bao-chan;ZHANG Qiu-hua;SUN Gui-yuan;Department of Histology and Embryology, College of Basic Medical Science, China Medical University;Liaoning Institute for Food and Drug Control;Department of Basic Pharmacology, Liaoning University of Traditional Chinese Medicine; |
| |
Abstract: | Objective To investigate the preliminary pharmacological screening of Cassia nomame. Methods The effect of aqueous extract from C. nomame on gastrointestinal motor function was investigated by assessing the intestinal transit rate (ITR) of charcoal modeled into gastrointestinal motility dysfunction (GMD) by the administration of dopamine, atropine, or noradrenaline to the rats, respectively. Diuresis was studied in vivo by estimating the urine output. The anti-inflammatory activity was expressed as the percentage of swelling reduction by comparison on the mean thickness of ear swelling in mice. Results The ITR in these GMD animals was significantly retarded compared to that in normal animals. The retardation, however, was significantly inhibited by the ig administration of C. nomame (2 g/kg) for all GMD animals. The results suggested that C. nomame had the potential for development into a prokinetic agent that could prevent or alleviate GMD in patients. C. nomame increased urine output and suppressed significantly ear swelling induced by dirnethyl benzene in mice. Conclusion C. nomame could increase the gastrointestinal contractile activity of rats and has the effects of diuresis and anti-inflammation. |
| |
Keywords: | Cassia nomame diuresis ear swelling gastrointestinal motility dysfunctions intestinal transit |
本文献已被 CNKI ScienceDirect 等数据库收录! |
| 点击此处可从《中草药(英文版)》浏览原始摘要信息 |
|
点击此处可从《中草药(英文版)》下载免费的PDF全文 |