应用高分辨率MRI研究大脑中动脉狭窄率在脑梗死与短暂性脑缺血发作患者中的差异

目的应用3．0T高分辨率MRI（high．resolutionMRI，HRMRI）研究大脑中动脉（middlecerebralartery，MCA）粥样硬化性狭窄程度在脑梗死与短暂性脑缺血发作（TIA）患者中的差异。材料与方法2011年4月至2013年4月连续入组经MRA或DSA证实的症状性MCAM1段动脉粥样硬化性狭窄患者91例，使用3．0TMR扫描仪对狭窄段进行HRMRI检查，测量并计算血管狭窄率，并加扫DWI、T2WI及黑水序列，明确有无脑梗死。结果78例患者纳入最终分析，其中脑梗死患者46例，HRMRI上测得的狭窄率为0．72±0．21；TIA患者32例，HRMRI上测得的狭窄率为0．72±0．20，二者差异无统计学意义（t=-0．10，P〉0．05）。结论大脑中动脉M1段的狭窄程度在脑梗死与TIA患者中无差异，提示血管狭窄程度并非脑梗死发生的决定性因素。

High-resolution MRI study of middle cerebral artery stenosis rate differences in infarct and TIA patients

Objective： To investigate the stenosis rate differences of atherosclerotic middle cerebral artery （MCA） between cerebral infarct and TIA patients with high- resolution magnetic resonance imaging （HR MRI）. Materials and Methods： Ninety- one consecutive patients with symptomatic atherosclerotic stenosis at M l segment of MCA on MRA or DSA were enrolled from April 2011 to April 2013. HRMRI was performed on the target segment by using a 3.0 T MR scanner. Stenosis rate was calculated as vessel area at maximal lumen narrowing/reference vessel area. Diffusion weighted imaging （DWI）, T2WI and dark-fluid sequences were performed to make sure if infarct occurred. Resuits： Seventy-eight patients were included in the final analysis, including 46 patients with infarct, the stenosis of which is 0.72±0.2 1, and 32 patients with TIA, the stenosis rate 0.72±0.20. The rate difference between patients with infarct and TIA was not statistically significant （t=- 0.10, P〉0.05）. Conclusions： The stenosis rates of M1 segment of MCA in patients with infarct and TIA have no difference, suggesting that the stenosis rate of M1 segment of MCA is not the determining factor of infarction.