| 地塞米松对癫痫大鼠脑组织内IgG免疫反应阳性细胞分布的影响 |
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| 引用本文： | 郑乃智,阮旭中,王群,李震中,刘绍春. 地塞米松对癫痫大鼠脑组织内IgG免疫反应阳性细胞分布的影响[J]. 临床神经电生理学杂志, 1999, 0(1) |
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| 作者姓名： | 郑乃智 阮旭中 王群 李震中 刘绍春 |
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| 作者单位： | 同济医科大学附属同济医院神经病学教研室，山东潍坊医学院附属医院神经科 |
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| 摘 要： | 目的：研究地塞米松对大鼠脑免疫反应的影响，探讨其对某些类型癫痫的治疗机理。方法：美解眠致痫及致痫前后分别给予地塞米松的大鼠用免疫细胞化学法观察ＩｇＧ免疫反应阳性（ＩｇＧＩＲ）细胞在大鼠脑组织内分布。结果：致痫前给予地塞米松大鼠脑皮层和海马ＩｇＧＩＲ细胞数比单纯致痫组减少（Ｐ＜００１，Ｐ＜００５）；致痫后给予地塞米松组大鼠，只有海马ＩｇＧＩＲ细胞数比单纯致痫组增多（Ｐ＜００１）。结论：地塞米松对脑免疫反应的调节在某些类型癫痫的治疗中可能有一定意义。
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| 关 键 词： | 大鼠 癫痫 地塞米松 免疫球蛋白G |
Influence of dexamethasone on distribution of immunoglobulin G immunoreactivity positive cells in epileptic rat brain. |
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| Zheng Naizhi,Ruan Xuzhong,Wang Qun,et al Dept. of Neurology,Tongji Hospital,Tongji Medical University,Wuhan. Influence of dexamethasone on distribution of immunoglobulin G immunoreactivity positive cells in epileptic rat brain.[J]. Journal of Clinical Electroneurophysiology, 1999, 0(1) |
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| Authors: | Zheng Naizhi Ruan Xuzhong Wang Qun et al Dept. of Neurology Tongji Hospital Tongji Medical University Wuhan |
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| Abstract: | Objectives:To study the influence of dexamethasone on immunoreactivity in rat brain and explore the mechanism of dexamethasone in treatment of certain types of seizures.Methods:The distribution of immunoglobin G immunoreactivity (IgG IR) positive cells in the brain of bemegride induced epileptic and dexamethasone given (before and after seizures) rats was studied through immunocytochemistry.Results:The number of IgG IR cells in the cortex and hippocampus with dexamethasone administration before inducement was decreased as compared with the simple induced epilepsy ( P <0.01, P <0.05).However, the number of IgG IR cells of rats with dexamethasone administration after in ducing seizures was increased only in the hippocampus ( P <0.01).Conclusions:The regulation of dexamethasone on the brain immunoreactivity might be of certain significance in the treatment of some types of epilepsy. |
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| Keywords: | Rat Epilepsy Dexamethasone Immunoglobulin G |
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