Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma |
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Authors: | Peter Würl Axel Meye Dieter Berger Christine Lautenschläger Matthias Bache Hans-Jürgen Holzhausen Hannelore Schmidt Henning Dralle Friedrich-Wilhelm Rath H. Taubert |
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Affiliation: | (1) Clinic of General Surgery, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06120 Halle/Saale, Germany, DE;(2) Institute of Pathology, Martin-Luther-University of Halle, Magdeburger Str. 14, D-06097 Halle/Saale, Germany Tel: +49 345 557 1293; Fax: +49 345 557 1295; e-mail: helge.taubert@medizin.uni-halle.de, DE;(3) Institute of Biometry and Informatics, Martin Luther University Halle-Wittenberg, Krausenstrasse 40, D-06097 Halle/Saale, Germany, DE;(4) Department of Radiotherapy, Martin Luther University Halle-Wittenberg, Dryanderstrasse 4 – 7, D-06097 Halle/Saale, Germany, DE |
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Abstract: | The growth regulatory function of the retinoblastoma protein (RB) can be suppressed by mdm2 via RB/mdm2 interaction by perturbation of the RB suppression of the E2F function. The goal of this study was to examine the clinical value of immunohistochemical (IHC) RB detection and its relationship to mdm2 overexpression in a cohort of 198 adult primary soft-tissue sarcomas (STS). RB overexpression reveals, multivariately, a correlation with survival (RR = 1.59, P = 0.037) as well as mdm2 positivity (RR = 2.32, P = 0.0035). Stratification of RB results to mdm2 staining shows a prognostic graduation in four levels. Patients with positivity for both antibodies have the highest risk (RR = 3.30, P = 0.002) and the poorest prognosis (projected 5-year survival rate, 18.6%); those with negativity for both antibodies show the most favourable prognosis (projected 5-year survival rate, 63.4%). Intermediately, an isolated RB overexpression (projected 5-year survival rate, 46.1%) is more favourable than an isolated mdm2 positivity (projected 5-year survival rate, 33.5%). To sum up, this study proves that RB and mdm2 overexpression have an individual and also an additive effect on prognosis in STS. Received: 3 June 1997 |
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Keywords: | Retinoblastoma protein Murine double minute protein Immunohistochemistry Prognosis |
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