| 外周血p53基因多态性与中国人瘢痕疙瘩相关性的Meta分析 |
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| 引用本文： | 吴严,刘佳丽,陈晶,孙艳,李远宏,高兴华,陈洪铎.外周血p53基因多态性与中国人瘢痕疙瘩相关性的Meta分析[J].中国循证医学杂志,2011,11(6):651-654. |
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| 作者姓名： | 吴严 刘佳丽 陈晶 孙艳 李远宏 高兴华 陈洪铎 |
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| 作者单位： | 1. 中国医科大学附属第一医院皮肤科,沈阳,110001
2. 中国医科大学附属第四医院肿瘤科,沈阳,110001 |
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| 基金项目： | 2007年教育部创新团队基金 |
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| 摘 要： | 目的系统评价外周血中p53基因第72密码子多态性与中国人瘢痕疙瘩的相关性。方法计算机检索PubMed、EBSCO、CNKI、CBM及万方数据库,收集外周血中p53基因第72密码子多态性与中国人瘢痕疙瘩相关性的病例对照研究。检索时间为建库至2010年8月。用Meta分析方法综合评价外周血中p53基因第72密码子基因型Pro/Pro vs.Arg/Arg、Pro/Pro vs.Pro/Arg及等位基因型Pro vs.Arg在中国人瘢痕疙瘩组与对照组中是否有差异。结果共纳入5个研究,包括瘢痕疙瘩患者328例及对照420例。Meta分析结果显示:具有基因型Pro/Pro的中国人群发生瘢痕疙瘩的风险与具有基因型Arg/ArgOR=2.17,95%CI(0.86,5.47)]或基因型Pro/ArgOR=1.90,95%CI(0.92,3.93)]的人群相当,而等位基因Pro引起瘢痕疙瘩发病风险高于等位基因ArgOR=1.86,95%CI(1.03,3.35)]。结论中国人外周血中p53基因第72密码子等位基因Pro与瘢痕疙瘩发病有关。
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| 关 键 词： | p53 多态性 瘢痕疙瘩 Meta分析 中国人群 |
Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population: A Meta-analysis |
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| WU Yan,LIU Jia-li,CHEN Jing,SUN Yan,LI Yuan-hong,GAO Xing-Hua,CHEN Hong-Duo.Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population: A Meta-analysis[J].Chinese Journal of Evidence-based Medicine,2011,11(6):651-654. |
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| Authors: | WU Yan LIU Jia-li CHEN Jing SUN Yan LI Yuan-hong GAO Xing-Hua CHEN Hong-Duo |
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| Institution: | WU Yan1,LIU Jia-li2,CHEN Jing1,SUN Yan1,LI Yuan-hong1,GAO Xing-Hua1,CHEN Hong-Duo1 1.Department of Dermatology,the First Hospital of China Medical University,Shenyang 110001,China,2.Department of Oncology,the Fourth Hospital of China Medical University |
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| Abstract: | Objective To clarify the correlation of p53 codon 72 polymorphism in peripheral blood with keloid susceptibility in Chinese population.Methods All the literatures of case-control research on the correlation between p53 codon 72 polymorphism in peripheral blood and keloid in Chinese population were searched in PubMed,EBSCO,CNKI,CBM,and WanFang Data from their establishment to August 2010.Meta-analyses were performed to detect whether there were differences between the keloid group and the control group about... |
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| Keywords: | p53 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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