| 异甘草酸镁与复方甘草酸单胺治疗血液肿瘤化疗后药物性肝损害的疗效比较 |
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| 引用本文： | 章志学. 异甘草酸镁与复方甘草酸单胺治疗血液肿瘤化疗后药物性肝损害的疗效比较[J]. 实用临床医药杂志, 2011, 15(13) |
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| 作者姓名： | 章志学 |
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| 作者单位： | 江西省吉安市中心人民医院,血液科,江西,吉安,343000 |
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| 摘 要： | 目的比较异甘草酸镁与复方甘草酸单胺治疗血液肿瘤化疗后药物性肝损害的临床疗效与不良反应。方法选取48例血液肿瘤化疗后药物性肝损害患者,随机分为2组,各24例。异甘草酸镁组予异甘草酸镁注射液150 mg,复方甘草酸单胺组予复方甘草酸单胺注射液60 mL,2组试剂均加入5%葡萄糖注射液250 mL静滴,每日1次,疗程均为2周。观察治疗后临床症状、体征、肝功能改善情况及不良反应。结果 2组治疗后临床症状、体征及肝功能指标较治疗前均有明显改善,改善率无显著性差异(P>0.05),但在复常天数上有显著性差异(P<0.05)。异甘草酸镁组显效率明显高于复方甘草酸单胺组(P<0.05)。异甘草酸镁组未出现明显不良反应;复方甘草酸单胺组发生颜面部水肿4例,血压升高1例。结论异甘草酸镁治疗血液肿瘤化疗后药物性肝损害的疗效优于复方甘草酸单胺,且副作用显著低于复方甘草酸单胺。
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| 关 键 词： | 异甘草酸镁 复方甘草酸单铵 血液肿瘤 药物性肝损害 |
Comparison of the clinical effect of Magnesium Isoglycyrrhizinate and Compound Ammonium Glycyrrhetate on drug- induced liver injury after blood cancer chemotherapy |
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| ZHANG Zhi-xue. Comparison of the clinical effect of Magnesium Isoglycyrrhizinate and Compound Ammonium Glycyrrhetate on drug- induced liver injury after blood cancer chemotherapy[J]. Journal of Clinical Medicine in Practice, 2011, 15(13) |
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| Authors: | ZHANG Zhi-xue |
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| Abstract: | Objective To compare the clinical effect and adverse reactions of Magnesium Isoglycyrrhizinate(MI) and Compound Ammonium Glycyrrhetate(CAG) on drug-induced liver injury(DILI) after blood cancer chemotherapy.Methods Forty-eight cases of DILI after blood cancer chemotherapy were divided into two groups.The patients in MI group(n=24) were given MI injection 150 mg,while CAG group(n=24) was given CAG injection 60mL.Both groups were added 250 mL 5% glucose injection,once every day,and continually vein injected f... |
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| Keywords: | Magnesium Isoglycyrrhizinate Compound Ammonium Glycyrrhetate blood cancer drug-induced liver injury |
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