循证医学理念下关于干预措施研究设计方案选择的思考

尽管来自随机对照试验的证据被认为是高级别的证据,但往往由于外推性较低而不能有效地运用于临床实践。随机对照设计和非随机设计提供的证据具有互补性和互参性,不同的研究设计适合不同的研究阶段,回答不同的研究问题,评价干预措施时需根据研究目的、可行性、权衡不同设计模式的优势和不足,选择合适的研究设计。

Reflections under Evidence-Based Medicine on the Intervention Clinical Research Designs

Although the evidence from randomized controlled trials(RCTs) is regarded as a golden standard,it often fails to be applied in clinical practice for lack of generalizability.Evidence from either RCTs or non-RCTs is mutually complementary and referred.Different designs are suitable for different stages and can resolve different issues.During evaluation of an intervention,the proper research design should be selected in accordance with the objective,feasibility,and merits and limitations of different design m...