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| 芎芍胶囊及丹参对大鼠缺血心肌血管新生的作用 | |
| 引用本文： | 严萍,林久茂,陈宇宁,赵锦燕,庄群川,陈美华,叶盈,黄飞翔. 芎芍胶囊及丹参对大鼠缺血心肌血管新生的作用[J]. 中西医结合心脑血管病杂志, 2011, 9(7): 836-837 |
| 作者姓名： | 严萍 林久茂 陈宇宁 赵锦燕 庄群川 陈美华 叶盈 黄飞翔 |
| 作者单位： | 1. 福建省中医药大学附属第二人民医院,350003 2. 福建省中西医结合研究院 3. 福建省中医药大学附属第二人民医院 |
| 基金项目： | 为陈可冀中西医结合发展基金资助项目 |
| 摘 要： | 目的探讨中成药芎芍胶囊及丹参对心肌梗死大鼠缺血心肌血管新生的影响。方法采用开胸结扎冠状动脉左前降支建立心肌梗死模型,清洁级(或SPF级)SD大鼠24只(雌雄各半)分为3组,即模型组、芎芍胶囊组、丹参组,每组8只,分别用生理盐水、芎芍胶囊、丹参按中剂量进行灌胃给药,连续给药。6周后采集血,分离样本,并按规定保存,用免疫组化评分法、血管新生相关因子检测法;检测各组缺血心肌内皮细胞生长因子(VEGF)、成纤维细胞生长因子(FGF)、表皮细胞生长因子(EGF)、转化生长因子(TGF)、血小板源生长因子(PDGF)等促血管生成因子的表达。结果芎芍胶囊组对VEGF、EGF的促进作用较丹参组、对照组有统计学意义(P<0.05),其中芎芍胶囊组、丹参组对FGF的促进作用与对照组比较均有统计学意义(P<0.05),对照组对TGF、PDGF促进作用较芎芍胶囊组、丹参组有统计学意义(P<0.05)。结论中药具有促进心肌梗死大鼠缺血心肌血管新生、提高心肌梗死大鼠心肌细胞VEGF、FGF、EGF蛋白的表达、具有保护心肌缺血性损伤的作用。 |
| 关 键 词： | 芎芍胶囊 丹参 心肌梗死 血管新生 |
Effect of Xiongshao Capsule and Danshen on Angiogenesis in Ischemic Myocardium of Rats with Myocardial Infarction |
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| Yan Ping,Lin Jiumao,Chan Yunning,et al The Second People''s Hospital,Fujian University of Traditional Chinese Medicine. Effect of Xiongshao Capsule and Danshen on Angiogenesis in Ischemic Myocardium of Rats with Myocardial Infarction[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2011, 9(7): 836-837 | |
| Authors: | Yan Ping Lin Jiumao Chan Yunning et al The Second People''s Hospital Fujian University of Traditional Chinese Medicine |
| Affiliation: | Yan Ping,Lin Jiumao,Chan Yunning,et al The Second People's Hospital,Fujian University of Traditional Chinese Medicine(Fuzhou 350003) |
| Abstract: | Objective To investigate the effect of Xiongshao capsule and Danshen on angiogenesis in ischemic myocardium of rats with myocardial infarction.Methods T The left anterior descending coronary artery were ligated to establish the myocardial infarction model.Twenty-four clean grade(or SPF grade) Sprague-Dawley(SD) rats were were divided into three groups(n=8):Model group intragastrically administered by saline,Xiongshao capsule group intragastrically administered by Xiongshao capsule,Danshen group intragastric... |
| Keywords: | Xiongshao capsule Danshen myocardial infarction angiogenesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |