IL-10在成人牙周炎炎症牙龈组织中的检测

目的：探讨白细胞介素10 （IL 10）在成人牙周炎不同临床状态下牙龈组织中的表达。 方法： 采用免疫组织化学SABC法检测IL 10在24例成人牙周炎（包括脓肿组12例和治疗组12例）、10例牙龈炎患者（牙龈炎组）和6例牙周健康者（对照组）牙龈组织中的表达。结果：脓肿组IL 10的表达量低于对照组、牙龈炎组及治疗组（P＜0.05、P＜0.01、P＜0.01），治疗组IL 10的表达量高于对照组及牙龈炎组（P＜0.01、P＜0.01）。结论：牙周炎活动性病变IL 10表达减少，牙周炎治疗后IL 10表达增加，IL10在牙周组织的修复中发挥保护作用。

Expression of IL-10 in gingival lesion in adult periodontitis

Objective: To investigate the expression of IL-10 in gingival tissues of various clinical stages in adult periodontitis.Methods: Immunohistochemistry SABC method was used to semi-quantitatively measure the expression of IL-10 in 24 adults with periodontits(12 in periodontal abscess group and 12 in treatment group),10 patients with gingivitis and 6 healthy controls.Results: The quantity of IL-10 was lower in abscess group than that in healthy controls,gingivitis and treatment group,respectively(P<0.05,P<0.01,P<0.01),and it was significantly higher in treatment group than that in healthy controls and gingivitis group(P<0.01,P<0.01).Conclusion: The expression of IL-10 decreases in the activity of periodontitis,but increases after treatment,suggesting IL10 acts as a protective role in the restoration of periodontal tissues.