| 橙皮苷降血脂作用的实验研究 |
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| 引用本文： | 李慧,杨中林.橙皮苷降血脂作用的实验研究[J].中医药学报,2010,38(1):23-24. |
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| 作者姓名： | 李慧 杨中林 |
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| 作者单位： | 中国药科大学,江苏,南京,210009 |
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| 基金项目： | 科技部十一五科技支撑计划课题 |
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| 摘 要： | 目的:研究橙皮苷是否具有降血脂作用以及降脂最佳剂量,以便指导新药研发和临床用药。方法:采用蛋黄乳造模的小鼠高脂血症模型,分别给予不同剂量的橙皮苷样品,测定小鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的浓度。结果:高剂量的橙皮苷能显著降低小鼠血清TC、TG、LDL-C的值,并能升高HDL-C的值。结论:高低剂量的橙皮苷均具有显著的降血脂作用,且高剂量组作用明显强于低剂量组。
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| 关 键 词： | 橙皮苷 TC TG LDL-C HDL-C |
Experimental Study on the Antihyperlipidemia Effect of Hesperidin |
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| LI Hui,YANG Zhong-lin.Experimental Study on the Antihyperlipidemia Effect of Hesperidin[J].Acta Chinese Medicine and Pharmacology,2010,38(1):23-24. |
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| Authors: | LI Hui YANG Zhong-lin |
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| Institution: | LI hui,YANG Zhong-lin(China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Objective:To study if the Hesperidin could influenced high blood lipid level,and to provide evidence in developing new drugs on antihyperlipidemia.Methods: Hyperlipidemia mice model was established by celiac injection of 75% egg-yolk emulsion.Then the animals were administrated with samples comprising equal flavonoids of different doses from Pericarpium citrir eticulatae.The total cholestrol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and high density lipop rotein-cholesterol(HDL-C)in se... |
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| Keywords: | TC TG LDL-C HDL-C |
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