Postsplenectomy type-1 hypersensitivity response: a correlation between IL-4 and IgE serum levels |
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| Authors: | Miniello Stefano Cristallo Graziana Testini Mario Balzanelli Mario Giosuè Marzaioli Rinaldo Venezia Pietro Lissidini Germana Petrozza Dino Nacchiero Michele |
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| Institution: |
a Section of Emergency and Trauma Surgery, Department of Applications in Surgery of the Innovative Technologies, University of Bari Medical School, Bari, Italy
b Section of General Surgery and Clinical Oncology, Department of Applications in Surgery of the Innovative Technologies, University of Bari Medical School, Bari, Italy
c Postgraduate School in Thoracic Surgery, University of Bari Medical School, Bari, Italy
d 2nd General Surgery, University of Bari Medical School, Bari, Italy |
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| Abstract: | Authors demonstrated the presence of allergic manifestations in splenectomized patients following traumatic rupture of this organ. In particular, allergic diathesis, as supported by serum IgE increase, was exclusively found in patients with preserved T helper (h)-2 lymphocyte function. Th-2 function was monitored by measuring serum levels of interleukin (IL)-4, a cytokine involved in IgE synthesis. On the opposite, in splenectomized individuals with a reduced Th-2 function as supported by lower IL-4 serum levels, no IgE increase and allergic manifestations were detectable. On these grounds, authors hypothesize that allergic manifestations may be correlated to splenectomy since its exeresis may favor the persistence of antigens in the blood. Consequentially, in patients with a preserved Th-2 function, antigenic overload may lead to IgE increase and allergy onset. |
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| Keywords: | Allergy IgE Interleukin-4 Splenectomy Trauma |
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