Prognostic value of interleukin-6 during a 3-year follow-up in patients with acute ST-segment elevation myocardial infarction |
| |
Authors: | Jing Tan Qi Hua Jing Li Zhenxing Fan |
| |
Institution: | (1) Department of Cardiology and Angiology, Elisabeth Hospital Essen, Klara-Kopp-Weg 1, 45138 Essen, Germany;(2) Department of Diagnostic and Interventional Radiology and Neuroradiology, University of Essen, Essen, Germany |
| |
Abstract: | Accumulating evidence suggests that inflammation plays an essential role in the pathogenesis of atherosclerosis. This recognition
has stimulated the evaluation of different inflammatory markers as potential predictors of cardiovascular risk. However, the
existing data are limited and controversial. This study was designed to simultaneously measure serum levels of interleukin-6
(IL-6), soluble CD40 ligand (sCD40L), metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in
patients with acute ST segment elevation myocardial infarction (STEMI) and to evaluate their ability to predict prognosis.
A prospective cohort study was conducted with 263 patients with first STEMI who were admitted to our institute within 6 h
of symptoms onset. Clinical data were recorded and serum admission levels of IL-6, sCD40L, MMP-9, and TIMP-1 were measured
by sandwich enzyme-linked immunosorbent assay. The patients were then followed prospectively for the occurrence of cardiovascular
mortality for 3 years. Follow-up information was available for 228 patients (86.7%) from the 263 STEMI patients; 34 patients
died from cardiovascular causes during the 3-year follow-up period. Kaplan-Meier plots demonstrated a significant increase
in cardiovascular mortality with increasing IL-6 levels (χ2 = 14.13, P = 0.0002, by log-rank test). Logistic regression analysis revealed that IL-6 was an independent predictor for cardiovascular
mortality. The present study indicates that elevated admission level of IL-6 could provide valuable information for long-term
risk stratification in patients with STEMI. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|