| 毒黄素对黄嘌呤氧化酶作用的影响 |
| |
| 引用本文： | 任维栋,赵乃昕.毒黄素对黄嘌呤氧化酶作用的影响[J].潍坊医学院学报,1990,12(3):20-23. |
| |
| 作者姓名： | 任维栋 赵乃昕 |
| |
| 作者单位： | 潍坊医学院生物化学教研室，潍坊医学院微生物学教研室，潍坊医学院生物化学教研室，潍坊医学院生物化学教研室，潍坊医学院生物化学教研室 |
| |
| 摘 要： | 利用从椰毒假单胞菌(Pseudomona cocovenenans)中所分离提取的毒黄素(toxoflavin)对黄嘌呤氧化酶(EC.1.2.3.2)作用的动力学试验表明,毒黄素是此酶的非必需激活剂,而且对以次黄嘌呤为底物的反应的激活作用明显高于以黄嘌呤为底物的反应。此激活作用属于部分混合型。这一结果为探寻毒黄素对人的致毒机理提供了一条重要线索。
|
| 关 键 词： | 毒黄素 黄嘌呤氧化酶 部分混合型激活作用 |
EFFECT OF TOXOFLAVIN ON THE ACTION OF XANTHINE OXIDASE |
| |
| Ren Weigong,Zhao Naixin,Yuan Yonghua,Lin Jinsheng,Lin Dianzhen.EFFECT OF TOXOFLAVIN ON THE ACTION OF XANTHINE OXIDASE[J].Journal of Weifang Medical College,1990,12(3):20-23. |
| |
| Authors: | Ren Weigong Zhao Naixin Yuan Yonghua Lin Jinsheng Lin Dianzhen |
| |
| Institution: | Weifang Medical College |
| |
| Abstract: | The kinetic studies of effect of toxoflavin on the action of xanthine oxidase (EC 1, 2, 3, 2) which was extracted from Pseudomons cocovenenans showed that toxoflavin was nonessential activator for the enzyme, and the activation in condition of hypoxanthine as substrate was more marked than xanthine. The activation obeyed the partial actvation type. These results provide us a lead for searching toxic mechanism of toxoflavin for human. |
| |
| Keywords: | toxoflavin xanthine oxidase partial activation |
| 本文献已被 CNKI 维普 等数据库收录！ |
