冠心病合并高尿酸血症患者的内皮功能改变及性别差异

目的研究老年冠心病合并高尿酸血症患者的内皮功能受损情况及是否存在性别差异。方法选择86例55岁以上已确诊冠心病且基础尿酸>416μmol/L的患者为研究对象,男性患者共44例,女性患者共42例;另选60例血尿酸正常的冠心病患者,男、女各30例,作为对照组。分别检测总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、一氧化氮、内皮素等指标。结果男女两组冠心病合并高尿酸血症患者的内皮功能受损情况较血尿酸正常组均明显加重(P<0.01),而女组患者受损严重程度高于男组(P<0.05)。结论高尿酸血症是冠心病的独立危险因素,加重冠心病患者内皮功能受损状况,并且绝经后女性较男性更显著。

The changes of endothelial function in coronary heart disease patients complicated with hyperuricemia

Objective To study vascular endothelial function among older patients with coronary artery dis- ease accompanying hyperuricemia. Methods 86 inpatients with coronary artery disease accompanying hyperuricemia were involved in this study （44 males ;42 females, mean age ：69.1 ±10.7）. 60 inpatients with coronary artery disease and normal uric acid were divided into control groups（30 males,30 females, mean age：65.7 ± 9.4）. TC, TG, HDL, LDL, NO, ET, UA were measured for each group at the same time. Results The nitric oxide level of patients with coronary artery disease accompanying hyperuricemia was observably lower than that in the control group （P 〈 0.01 ）. The females were even more obvious than males （ P 〈 0.05 ）. Conclusion Hyperuricemia is a risk factor of coronary artery disease. The endothelial function injury in post-menopausal women is more obvious that males.