非小细胞肺癌患者血清血管内皮生长因子测定的临床意义

目的:监测血清血管内皮生长因子(VEGF)对评估非小细胞肺癌(NSCLC)患者预后的判断价值。方法:采用ELISA方法检测54例NSCLC患者血清VEGF的含量,分析血清VEGF水平与反映病程进展情况的TNM分期中T、N、M各参数以及患者生存期之间的关系。结果:血清VEGF水平与肺癌侵袭范围密切相关,T3鄄T4患者血清VEGF升高率明显高于T1鄄T2患者(P<0.01)。血清VEGF水平与淋巴结转移程度密切相关,N3患者血清VEGF较N1鄄N2患者明显升高(P<0.01)。有远处转移的患者中72.7%(16/22)血清VEGF升高,而无远处转移的患者血清VEGF升高仅40.6%(13/32),两者差异有显著性(P<0.05)。血清VEGF与患者生存期亦密切相关,生存≥6个月者37.5%(9/24)的患者血清VEGF升高,而生存期<6个月者66.7%(20/30)的患者血清VEGF升高,两者间差异有显著性(P<0.05)。结论:血清VEGF与NSCLC患者的病程进展及生存期相关,是一种有用的预后判断指标。

Clinical Significance of Detecting Serum Vascular Endothelial Growth Factor in Patients with Non-small-cell Lung Carcinoma

To evaluate the role of serum vascular endothelial growth factor(VEGF)level as a factor in prejudging prognos is in patients with non-small-cell lung carcinoma.Methods:Serum VEGF levels of54patients with non-small-cell lung carcinoma were detected by ELISA.The relation between serum VEGF level and TNM classification and survival time were analyzed.Results:Serum VEGF level was correlated with tumor local extension.The serum VEGF level was higher in the patients with T 3 -T 4 than that in the patients with T 1 -T 2 [69.2%(27/39)versus13.3%(2/15)],P<0.01).Serum VEGF level was also correlated with lymph nodes and distant metastasis(P<0.01,P<0.05).In patients survived for more than6months,37.5%(9/24)had serum VEGF level elevated,while for those survived for less than6months,66.7%(20/30)had serum VEGF level elevated(P<0.05).Conclusion:Serum VEGF level is correlated with progression and survival in patients with non-small-cell lung carcinoma,and it is an effective prognostic factor for non-small-cell lung cancer.