药物性肝病60例临床分析

目的分析60例药物性肝病临床特点，以利临床医生重视药物性肝病的预防、诊断与治疗，避免延误诊治。方法采用回顾性分析60例药物性肝病住院病人的用药史、临床表现、肝功能检查以及治疗转归作出综合分析。结果引起肝损害的药物中，以抗生素、抗肿瘤药物为主。药物性肝病的临床表现及肝功能检查与病毒性肝炎无明显差异，但合并有慢性肝炎的病人其病情较重。结论①引起药物性肝病的药物，以抗生素、抗肿瘤药多见，但中草药也不容忽视。②药物性肝病的临床表现为黄疸与转氨酶升高，与普通病毒性肝炎无明显特异性。经保肝、降酶、退黄治疗后，一般预后良好，但也可引起重症肝炎而死亡。③临床医师应重视药物性肝病的预防、诊断与治疗。

Clinical analysis of 60 cases with drug-induced liver diseases

Objective To analyze the etiology and clinical features of 60 patients with drug-induced liver disease, and make clinical physicians attach importance to the prevention, diagnosis and treatment to avoid misdiagnosis. Methods Data of 60 patients with drug-induced liver disease, including the medication history, clinical manifestation, liver function tests ,treatment and short-term effect were reviewed retrospectively. Results There are a great variety of drugs causing drug-induced liver disease, mainly including antibiotics, antituberculotics and antineoplastics. Both the cases of drug-induced liver disease and the ones of virus hepatitis have no significant differences in the clinical manifestation and liver function tests, but the patients of chronic hepatitis tend to be more seriously ill. Conclusions ①There are various kinds of drugs causing drug-induced liver disease ,mainly including antibiotics, antituberculotics and antineoplastics. Moreover, herbs should not be ignored. ②The clinical manifestations of the patients of drug-induced liver disease are jaundice and the elevated ALT levels ,which have no significant differences with the ones of virus hepatitis. After the therapy of liver protection, ALT decrease and jaundice treatment, the patients usually get well. But some cases may cause severe hepatitis and death. ③Clinical physicians should attach importance to the prevention, diagnosis and treatment of drug-induced liver disease.