Donated organ as a source of cytomegalovirus in orthotopic liver transplantation. |
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Authors: | S Sutherland P Bracken T G Wreghitt J O'Grady R Y Calne R Williams |
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Affiliation: | Virology Laboratory, Dulwich Hospital, London, England. |
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Abstract: | The importance of the donated organ as a source of CMV was assessed in 120 patients following orthotopic liver transplant and the CMV infections that developed in these patients were graded by severity. Forty-four recipients were CMV antibody negative pre-transplant. Eighteen of these received organs from CMV antibody positive donors and 15 (83%) developed primary CMV infections, 13 (87%) of which were symptomatic. Twenty-six received organs from CMV antibody negative donors and only 2 (8%) became CMV positive post transplant (P less than 0.001). These data suggest that there would be a considerable advantage in matching CMV antibody negative recipients with negative donors. Forty-five percent of secondary infections were asymptomatic compared with 12% of primary infections, and only 11% became disseminated compared with 53% of primary infections. The secondary infections that followed transplantation of an organ from a CMV antibody positive donor were more likely to be symptomatic and were more severe than those in patients who received seronegative livers. |
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Keywords: | donor transplantation CMV antibody negative pre-transplant |
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