Immunomodulatory Effects of γ-HCH (Lindane) in Mice |
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| Authors: | P Meera P R Rao R Shanker O Tripathi |
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| Institution: |
a Physiology Division, Central Drug Research Institute, Lucknow, INDIA
b Cell and Molecular Biology Lab., Department of Zoology, Osmania University, Hyderabad, INDIA
c Industrial Toxicology Research Centre, Lucknow, INDIA |
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| Abstract: | Mice were fed for 24 weeks with three different subtoxic dosages of γ-HCH (0.012, 0.12 and 1.2 mg/kg) mixed in powdered feed. The immunological profile was assessed at an interval of one month during the entire exposure period. Both the cell mediated and humoral components of immunity showed a biphasic response characterized initially by stimulation followed by suppression in a dose dependent manner. However, γ-HCH did not affect the functional properties of peritoneal macrophages. Histological changes in lymphoid organs were in accordance with the biphasic immunomodulatory effects of γ -HCH. |
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