螺内酯治疗经前期综合征的观察性研究

目的：观察螺内酯治疗经前期综合征（PMS）的疗效。方法：60例PMS患者随机分为螺内酯组（观察组,30例）及维生素B6组（对照组,30例）,并给予相应药物治疗;治疗前后分别使用焦虑自评量表（SAS）及抑郁自评量表（SDS）对患者焦虑及抑郁进行评分,并比较患者血浆醛固酮、血钾、血钠及尿量变化。结果：治疗前上述指标组间差异均无统计学意义（均P〉0.05）;治疗后观察组的SAS评分显著低于对照组,差异有统计学意义（P〈0.05）,但SDS评分组间差异无统计学意义。治疗后观察组醛固酮及血钠水平较治疗前明显降低,且明显低于对照组（P〈0.05或P〈0.01）;治疗后观察组尿量较治疗前增加,差异有统计学意义（P〈0.01）,且明显多于对照组（P〈0.01）,但2组治疗后的血钾水平差异无统计学意义。结论：螺内酯对PMS患者具有较理想的抗焦虑作用,并且可以改善体液代谢紊乱,其疗效优于维生素B6。

The Effect of Spirolactone in Patients with Premenstrual Syndrome

Objective: To evaluate the effect of spirolactone on patients with premenstrual syndrome (PMS). Methods: A total of 60 subjects were randomly divided into the spirolactone(treatment)and vitamin B6(control), with 30 subjects in each group. Scale of SAS and SDS were used to evaluate the severity of the anxiety and depression. Plasma aldosterone, sodion, potassiumion and 24 hrs urine volumes were measured to compare the degree of fluid retention. Results: There was no significant difference of all the indexes ...