胰腺癌小分子靶向药物的应用研究进展

胰腺癌起病隐匿，早期诊断困难，恶性程度高，死亡率高，发病率全球范围内呈上升趋势。以吉西他滨为代表的细胞毒类药物仍是目前标准胰腺癌化疗的主流用药，但疗效不理想。寻求新型靶向治疗药物和研究靶向药物结合细胞毒药物提高治疗效果和改善生存质量是当前关注的方向。本文将介绍近年来对胰腺癌治疗有阳性结果的小分子靶向药物，结合靶点的分子特性阐述靶向药物的作用机制的进展。

Research progression on application of small molecular targeted drugs for pancreatic cancer

Pancreatic cancer has features of hidden onset, difficult diagnosis at early stage, high malignant degree, high mortality, its incidence has a rising trend globally. The cytotoxic drugs such as gemcitabine are still the mainstream standard chemotherapy drugs for pancreatic cancer treatment, but the efficacy is not ideal. Seeking new targeted therapy and studying targeted drugs in combination with cytotoxic drugs to improve treatment effect and the quality of life is the current concerned direction. This article is going to introduce the targeted drugs which has positive results in treatment of pancreatic cancer in recent years, it illustrates the research progress on the mechanism of action of targeted drugs according to the properties of molecular targeted spots.