不同剂量布地奈德混悬液对哮喘急性发作患儿的疗效对比

目的探讨不同剂量布地奈德混悬液雾化吸入治疗小儿哮喘急性发作的临床疗效。方法将我院2012年3月至2014年3月收治的150例支气管哮喘急性发作患儿按不同治疗方案随机均分为对照组（低剂量布地奈德雾化吸入治疗）和观察组（高剂量布地奈德雾化吸入治疗），对两组患儿治疗效果及肺功能改善情况比较进行综合比较。结果观察组治疗总有效率（88．00％）明显高于对照组（74．67％），χ^2=4．3911，P〈0．05；两组患儿经治疗后的PEF、FEV1较治疗前均有明显升高（P〈0．05），但观察组PEF、FEV1较对照组升高明显（P〈0．05），两组均未见明显不良反应。结论高剂量布地奈德混悬液雾化吸入治疗小儿哮喘急性发作效果显著，安全性高。

Inhaling different doses of budesonide for acute asthma attack in children

Objective To investigate the clinical effect atomizedly inhaling different doses of budesonide for acute asthma attack in children. Methods 150 children acutely attacked by asthma and admitted into our hospital from March, 2012 to March, 2014 were randomly divided into a control group, atomizedly inhaling low dose of budesonide, and an observation group, atomizedly inhaling high dose of budesonide. The clinical effect of these two groups were comprehensively compared. Results The total effective rate of the observation group（ $8.00% ）was significantly higher than that of the control group（ 74.67% ） （P 〈 0.05）. PEF and FEV1 were statistically higher after than before the treatment in both groups（P 〈 0.05） and in the observation group than in the control group（P 〈 0.05）. No adverse reaction was observed in both groups. Conclusions Atomizedly inhaling high dose of budesonide for children acutely attacked by asthma is effective and safe.