| SLC30A8基因多态性与2型糖尿病易感性的meta分析 |
| |
| 引用本文： | 李春勇,张林,毛吉扬,石毅,马誓,鲁芳,王亚男.SLC30A8基因多态性与2型糖尿病易感性的meta分析[J].中国分子心脏病学杂志,2010,10(1):36-39. |
| |
| 作者姓名： | 李春勇 张林 毛吉扬 石毅 马誓 鲁芳 王亚男 |
| |
| 作者单位： | 1. 四川师范大学生命科学院,610101
2. 四川省人民医院,人类疾病基因研究四川省重点实验室,四川省医学科学院,610072 |
| |
| 摘 要： | 目的为了探讨SLC30A8(SNP:rs13266634)基因多态性与2型糖尿病(T2DM)易感性的关系。方法通过检索PubMed和CNKI数据库中有关SLC30A8基因多态性与2型糖尿病(T2DM)易感性关联研究的文献,用漏斗图评价发表偏倚,固定效应模型和随机效应模型进行meta分析,并检验异质性Q值和I2。此过程均在软件包LaunchStata9.0上完成。结果纳入11篇文献,得到12,100个2型糖尿病病例和14,907个对照。等位基因C相对于T的整体OR值为1.13(95%CI:1.09～1.17,P=0.000),CC对TT的OR为1.29值(95%CI:1.19～1.41,P=0.000)。结论SLC30A8(SNP:rs13266634)基因多态位点与2型糖尿病(T2DM)相关。
|
| 关 键 词： | 型糖尿病 基因多态性 Meta分析 等位基因 异质性 发表偏倚 固定效应模型 随机效应模型 易感性 胰岛素 |
Meta-analysis of the Association of SLC30A8 Gene Polymorphisms with Type 2 Diabetes |
| |
| LI Chun-yong,ZHANG Lin,MAO Ji-yang,SHI Yi,MA Shi,LU Fang,WANG Ya-nan.Meta-analysis of the Association of SLC30A8 Gene Polymorphisms with Type 2 Diabetes[J].Molecular Cardiology of China,2010,10(1):36-39. |
| |
| Authors: | LI Chun-yong ZHANG Lin MAO Ji-yang SHI Yi MA Shi LU Fang WANG Ya-nan |
| |
| Institution: | LI Chun-yong1,ZHANG Lin1,MAO Ji-yang1,SHI Yi2,MA Shi2,LU Fang2,WANG Ya-nan1.1College of life Science,Sichuan normal University,Chengdu,Sichuan,610101,China,2Sichuan Provincial Key Laboratory for Human Disease Gene,Sichuan Academy of Medical Science & Sichuan Provincial Peoples\' Hospital,610072 |
| |
| Abstract: | Objective To evaluate the association of gene polymorphism with type 2 diabetes.Methods Literature-based searching was conducted to collect data（from PubMed、CNKI and ect.） and two methods,there are,fixed-effects and random-effects mete-analysis,were performed to pool the odds ratio （OR）.Publication bias and study-between heterogeneity were also examined.All analyses were conducted in Stata software,version 9.0.Results The studies collected 11 papers data,and included 12,100 cases of T2DM and 14,907 controls,The pooled ORs of allele C vs T,genotype CC vs TT and genotype of SLC30A8 gene of T2DM was 1.13（95% CI：1.09～1.17,P=0.000）,1.29（95%CI：1.19～1.41,P=0.000） respectively.Conclusions The Meta-analysis indicated that SLC30A8 gene polymorphism （rs13266634） was associated with Type 2 Diabetes. |
| |
| Keywords: | T2DM Gene polymorphisms Meta-analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
