诺氟沙星治疗阿米巴肝脓肿

目的：探索新的、有效的治疗阿米巴肝脓肿的药物。方法：诺氟沙星０．３－０．４９，ｔｉｄ，ｐｏ×１５ｄ，治疗３０例（男性２２例，女性８例；年龄４５±ｓ３ａ）阿米巴肝脓肿病人。用０．５％甲硝唑１００ｍＬ静脉滴注（静滴），ｂｉｄ×（３－５）ｄ，以后改为０．４ｇ，ｔｉｄ，ｐｏ×（７－１０）ｄ治疗２９例作对照。２组合并细菌感染者均加用四环素１．０ｇ，ｑｄ，静滴５－７ｄ或用氨苄西林２．０ｇ，ｔｉｄ，ｉｖ×（５－７）ｄ。结果：诺氟沙星组在治疗有效率，体温恢复正常时间，平均住院无数与甲硝唑组相似（Ｐ＞０．０５）。但脓腔缩小时间短，肝区疼痛消失早，不良反应少（Ｐ＜０．０１或０．０５）。结论：诺氟沙星治疗阿米巴肝脓肿优于甲硝唑。

Norfloxacin in treatment of amebic liver abscess

AIM: To probe into new and effective medicines against amebic liverabscess. METHODS: Norfloxacin (0.3-0.4g , po, tid,15 d) was used to treat 30 patients with amebic liver abscess(M 22, F8; age 45±s 3 a), as compared with 0.5% metronidazole 100 mL, iv gtt, bid, 3-5 d, then 0.48, tid, po 7-10 d, in 29 patients. Tetracycline(1.0g, iv gtt, qd 5-7 d) or ampicillin(2.0g, iv, tid, 5-7d) were used in both groups accompanied by bacterial infection. RESULTS: The effective rates, temperature recovery time, and average hospitalization days were similar in both groups(P>0.05). However, the abscess cavity reduced more rapidly, liver pain disappeared sooner, and less adverse reactions in the norfloxacin group than in the metronidazole group(P<0.01 and P<0.05). CONCLUSION: Norfloxacin is superior to metrolnidzole in treating amebic liver abscess.