| 三株人白血病细胞系/SCID小鼠模型的建立及其生长特性 |
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| 引用本文： | 应红光,姜露,赵钧铭,胡晓莉,李长虹,褚建新.三株人白血病细胞系/SCID小鼠模型的建立及其生长特性[J].中国实验血液学杂志,1997(2). |
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| 作者姓名： | 应红光 姜露 赵钧铭 胡晓莉 李长虹 褚建新 |
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| 作者单位： | 中国医学科学院、中国协和医科大学血液学研究所，中国医学科学院、中国协和医科大学血液学研究所，中国医学科学院、中国协和医科大学血液学研究所，中国医学科学院、中国协和医科大学血液学研究所，中国医学科学院、中国协和医科大学血液学研究所，中国医学科学院、中国协和医科大学血液学研究所 天津 300020，天津 300020，天津 300020，天津 300020，天津 300020，天津 300020 |
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| 摘 要： | 本文报道了3株人白血病细胞系(HL-60,CEM和J6-1/SCID)小鼠模型的建立及其生长特点。发现人粒细胞白血病细胞系(HL-60)和T淋巴细胞系(CEM)给SCID小鼠静脉或腹腔移植后均发生全身性白血病,外周血可见白血病细胞。J6-1细胞(可能来自恶性淋巴瘤)眼眶后静脉移植后具有恶性淋巴瘤生长特点,在局部形成瘤块(与瘤细胞漏出血管有关),并侵及颌下淋巴结,无全身性播散。由此可见,人白血病细胞/SCID小鼠模型更类似于人类白血病,是进行人类白血病研究新的良好的模型。
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| 关 键 词： | 重度联合免疫缺陷小鼠 异种移植 白血病细胞系 HL-60细胞 CEM细胞 J6-1细胞 |
Establishment of Three Human Leukemic Cell Lines/SCID Mouse Models and Their Growth Properties |
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| YING Hong-Guang JIANG Lu ZHAO Jun-Ming HU Xiao-Li,LI Chang-Hong CHU Jian-Xin.Establishment of Three Human Leukemic Cell Lines/SCID Mouse Models and Their Growth Properties[J].Journal of Experimental Hematology,1997(2). |
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| Authors: | YING Hong-Guang JIANG Lu ZHAO Jun-Ming HU Xiao-Li LI Chang-Hong CHU Jian-Xin |
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| Abstract: | Establishment of three human leukemic cell lines/SCID mouse models and their growth properties were described. It was found that the human myelocytic leukemic cells (HL-60) and T-lymphocytic leukemic cells implanted into SCID mice appeared to be diffusive growth in whole body accompanied with tumor cells in peripheral blood. The growth pattern of J6-1 cells (may be originated from malignant lymphoma) looked like malignant lymphoma cells without diffusive spread, but forming local tumor. Therefore, human leukemia/SCID mouse model was more similar to human leukemia. It is a new and useful model to study human leukemia. |
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| Keywords: | severe combined immuno-difficiency mice xenograft leukemic cell line HL-60 cell CEM cell J6-1 cell |
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