| 贵州省新发现HIV-1毒株亚型特征研究 |
| |
| 引用本文： | 孙显光,何翔,李志坚,张信辉,申莉梅.贵州省新发现HIV-1毒株亚型特征研究[J].重庆医学,2011,40(29). |
| |
| 作者姓名： | 孙显光 何翔 李志坚 张信辉 申莉梅 |
| |
| 作者单位： | 1. 贵州省CDC艾滋病性病皮肤病防治研究所艾滋病二科,贵阳,550002
2. 中国CDC艾滋病艾滋病预防控制中心病毒免疫室,北京,100050 |
| |
| 基金项目： | 贵州省"十一五"重点攻关社发资金项目 |
| |
| 摘 要： | 目的 分析研究贵州省HIV-1亚型毒株分布及流行特征,为艾滋病防治及疫苗研制提供科学依据.方法 用套式基因扩增方法(PCR)扩增HIV-1毒株gag基因和env基因并测序分析.结果 128例样本扩增、测序成功119例,其中CRF01-AE亚型62例,CRF07-BC重组亚型49例,CRF08-BC重组亚型2例,B亚型6例.结论 本次研究贵州省HIV-1毒株以新发现的CRF01-AE重组亚型流行为主,CRF07-BC重组亚型次之,多亚型并存;分析结果提示贵州省HIV-1毒株亚型向性传播转变.
|
| 关 键 词： | HIV-1 亚型特征 基因 |
The Study of characteristic of new HIV-1 subtypes in Guizhou |
| |
| Sun Xianguang,He Xiang,Li Zhijian,Zhang Xinhui,Shen Limei.The Study of characteristic of new HIV-1 subtypes in Guizhou[J].Chongqing Medical Journal,2011,40(29). |
| |
| Authors: | Sun Xianguang He Xiang Li Zhijian Zhang Xinhui Shen Limei |
| |
| Institution: | Sun Xianguang1,He Xiang2,Li Zhijian1,Zhang Xinhui1,Shen Limei1(1.Guizhou Province CDC Institute of Prevention and Control AIDS/STD/ Dermatology,Guiyang,Guizhou 550002,China,2.Department of Virology and Immunology,Chinese CDC Center for AIDS Prevention and Control,Beijing 100050,China) |
| |
| Abstract: | Objective To study the HIV-1 subtype strain distribution and epidemic characteristics in Guizhou province and to provide scientific data for HIV/AIDS prevention and control.Methods Using a nested Polymerase Chain Reaction(PCR)to amplify gag and env gene of HIV strains,and for sequencing.Results 119 samples were amplified and sequenced successfully among 128 samples,of which 62 subtype CRF01-AE,49 recombinant subtype CRF07-BC,2 recombinant subtype CRF08-BC and 6 subtype B.Conclusion The study showed that new... |
| |
| Keywords: | HIV-1 characteristics genotype genes |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
