| 脐带间充质干细胞联合HLA单倍型相合造血干细胞治疗重型再生障碍性贫血的临床观察 |
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| 引用本文： | 李云龙,高蕾,陈幸华,张诚,高力,龚奕,刘焕凤,刘学,张曦.脐带间充质干细胞联合HLA单倍型相合造血干细胞治疗重型再生障碍性贫血的临床观察[J].重庆医学,2011,40(30). |
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| 作者姓名： | 李云龙 高蕾 陈幸华 张诚 高力 龚奕 刘焕凤 刘学 张曦 |
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| 作者单位： | 第三军医大学新桥医院血液科,重庆,400007 |
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| 基金项目： | 重庆市医学重点学科基金资助项目，第三军医大学新桥医院1520人才基金资助项目 |
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| 摘 要： | 目的 观察人脐带间充质干细胞(HUC-MSC)在联合人类白细胞抗原(HLA)单倍型相合移植治疗重型再生障碍性贫血的疗效和安全性.方法 对8例重型再生障碍性贫血患者进行HUC-MSC联合HLA单倍型相合移植治疗,观察移植疗效及相关并发症.结果 所有患者均重建供者造血,中性粒细胞大于0.5×109/L和血小板大于20×109/L的恢复中位时间分别为12.1 d和15.2 d.8例患者均出现粒细胞缺乏症伴感染,1例(12.5%)发生急性移植物抗宿主病(aGVHD),予甲泼尼松龙和布地奈德后治疗控制.巨细胞病毒(CMV)感染1例,无1 例发生肝静脉闭塞病(VOD).结论 HUC-MSC联合HLA单倍型相合移植治疗重型再生障碍性贫血安全有效,可加快造血重建.
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| 关 键 词： | 贫血 再生障碍性 人脐带间充质干细胞 联合 单倍型 |
Observation of transplantation of combined human umbilical cord derived mesenchymal stem cells and HLA haploidentical hematopoietic stem cells for aplastic anemia |
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| Li Yunlong,Gao Lei,Chen Xinghua,Zhang Cheng,Gao Li,Gong Yi,Liu Huanfeng,Liu Xue,Zhang Xi.Observation of transplantation of combined human umbilical cord derived mesenchymal stem cells and HLA haploidentical hematopoietic stem cells for aplastic anemia[J].Chongqing Medical Journal,2011,40(30). |
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| Authors: | Li Yunlong Gao Lei Chen Xinghua Zhang Cheng Gao Li Gong Yi Liu Huanfeng Liu Xue Zhang Xi |
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| Institution: | Li Yunlong,Gao Lei#,Chen Xinghua,Zhang Cheng,Gao Li,Gong Yi,Liu Huanfeng,Liu Xue,Zhang Xi(Hematology Department,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | Objective To investigate the efficacy and safety of transplantation of combined human umbilical cord derived mesenchymal stem cells and HLA haploidentical hematopoietic stem cells for aplastic anemia.Methods Eight patients with AA were carried out and treated with transplantation of combined human umbilical cord derived mesenchymal stem cells and HLA haploidentical hematopoietic stem cells,and the efficacy and correlated complication were observed.Results When the neutrophils count and platelet count in pat... |
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| Keywords: | anemia aplastic human umbilical cord derived mesenchymal stem cells combined partially mismatched peripheral blood stem cell |
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