| GLP-2对SAP大鼠肠黏膜屏障的保护作用 |
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| 引用本文： | 陈霞,赵宏贤,王忠琼,李昌平. GLP-2对SAP大鼠肠黏膜屏障的保护作用[J]. 重庆医学, 2011, 40(31): 3127-3128,3131,3116. DOI: 10.3969/j.issn.1671-8348.2011.31.003 |
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| 作者姓名： | 陈霞 赵宏贤 王忠琼 李昌平 |
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| 作者单位： | 1. 泸州医学院附属医院消化内科,四川泸州,646000
2. 泸州医学院组胚教研室,四川泸州,646000 |
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| 摘 要： | 目的探讨胰高血糖素样肽-2(GLP-2)在重症急性胰腺炎(SAP)肠黏膜屏障中的保护作用。方法 SD大鼠30只,随机分为3组:假手术组、SAP组、GLP-2组。采用胰管逆行注射3%牛磺胆酸钠溶液制作SAP模型。GLP-2组在制作SAP模型后,皮下注射GLP-2 0.1mg/kg,连续注射3d。3d后处死大鼠。透射电子显微镜观察小肠黏膜改变,检测各组血浆二胺氧化酶(DAO)及内毒素(ET)水平。结果 SAP组大鼠小肠黏膜出现明显病理损害;与SAP组相比较,GLP-2组小肠黏膜损伤显著减轻。SAP组DAO及ET水平明显高于假手术组(P<0.05);与SAP组比较,GLP-2组DAO及ET水平明显低于SAP组(P<0.05)。结论 GLP-2对SAP大鼠肠黏膜屏障功能具有一定保护作用。
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| 关 键 词： | 胰高血糖素样肽-2 肠黏膜 胺氧化酶 内毒素 |
Protective effects of GLP-2 on intestinal mucosal barrier in rats with severe acute pancreatitis |
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| Chen Xia,Zhao Hongxian,Wang Zhongqiong,Li Changping. Protective effects of GLP-2 on intestinal mucosal barrier in rats with severe acute pancreatitis[J]. Chongqing Medical Journal, 2011, 40(31): 3127-3128,3131,3116. DOI: 10.3969/j.issn.1671-8348.2011.31.003 |
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| Authors: | Chen Xia Zhao Hongxian Wang Zhongqiong Li Changping |
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| Affiliation: | Chen Xia1,Zhao Hongxian2,Wang Zhongqiong1,Li Changping1(1.Department of Digestive Disease,Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,China,2.Department of Histology and Embryology,Luzhou Medical College,China) |
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| Abstract: | Objective To explore the protective effects of glucagon like peptide-2(GLP-2) on intestinal mucosal barrier in rats with severe acute pancreatitis(SAP).Methods 30 rats were randomly divided into 3 groups:control group(sham operation group),severe acute pancreatitis model group(SAP group),GLP-2 group(SAP rats treated with GLP-2).The SAP rat models were established via retrograde injection of 3% sodium taurocholate to the pancreatic duct.Rats in GLP-2 group were peritoneally injected with GLP-2 with dose of 0... |
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| Keywords: | glucagon like peptide-2 intestinal mucosal amine oxidase endotoxins |
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