| 有限采样策略估算心脏移植受者霉酚酸体内暴露的研究 |
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| 引用本文： | 向红平,韩勇,周红,张菁,孙永丰,王艺茸,张敏,蔡杰. 有限采样策略估算心脏移植受者霉酚酸体内暴露的研究[J]. 中国临床药理学杂志, 2021, 0(1): 70-74 |
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| 作者姓名： | 向红平 韩勇 周红 张菁 孙永丰 王艺茸 张敏 蔡杰 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院药剂科;华中科技大学同济医学院附属协和医院湖北省重大疾病精准用药临床医学研究中心;华中科技大学同济医学院附属协和医院心血管外科;成都市第三人民医院药剂科;重庆医科大学附属儿童医院药剂科 |
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| 基金项目： | 国家自然科学基金资助项目(81703630);湖北省自然科学基金资助项目(2018CFB750)。 |
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| 摘 要： | 目的 用有限采样策略(LSS)建立心脏移植受者霉酚酸(MPA)血药浓度-时间曲线下面积(AUC)的简化预测模型.方法 共收集20例心脏移植受者,术后按相同剂量连续服用吗替麦考酚酯片或其分散片至少7d后,采集不同时间的全血样本,用LC-MS/MS法测定血浆MPA浓度.用WinNonlin软件以非房室模型计算其药代动力学参...
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| 关 键 词： | 霉酚酸 药代动力学 有限采样策略 心脏移植 治疗药物监测 |
Limited sampling strategy for the estimation of mycophenolic acid exposure in heart transplant recipients |
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| XIANG Hong-ping,HAN Yong,ZHOU Hong,ZHANG Jing,SUN Yong-feng,WANG Yi-rong,ZHANG Min,CAI Jie. Limited sampling strategy for the estimation of mycophenolic acid exposure in heart transplant recipients[J]. The Chinese Journal of Clinical Pharmacology, 2021, 0(1): 70-74 |
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| Authors: | XIANG Hong-ping HAN Yong ZHOU Hong ZHANG Jing SUN Yong-feng WANG Yi-rong ZHANG Min CAI Jie |
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| Affiliation: | (Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;Hubei Province Clinical Research Center for Precision Medicine for Critical Illness,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;Department of Pharmacy,The Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan Province,China;Department of Pharmacy,Children’s Hospital of Chongqing Medical University,Chongqing 400014,China) |
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| Abstract: | Objective To develop limited sampling strategy(LSS)models for prediction of the area under the concentration-time curve(AUC)of mycophenolic acid(MPA)in heart transplantation recipients.Methods Totally,20 heart transplantation recipients who received MPA at the same dose for more than 7 days were included for sampling at different time points.Plasma MPA concentrations were determined by a LC-MS/MS method.Non-compartmental model was used to calculate the pharmacokinetic parameters of MPA by WinNonlin.Multivariate linear regression analysis was used to establish LSS estimation models by SPSS 22.0.The selected models were validated by Bootstrap procedure and Bland-Altman analysis.Results The main pharmacokinetic parameters of MPA were as follows:AUC0-12 h was(27.36±8.37)mg·h·L^-1,tmax was(1.85±1.18)h,Cmax was(8.13±2.90)mg·L^-1,MRT0-12 h was(3.75±0.77)h,t1/2 was(10.47±11.03)h,and CL/F was(23.36±10.46)L·h^-1.The regression equations were obtained for 2,3 and 4 time points:MPA-AUC0-12 h=6.03+2.09 C2.0+10.11 C8.0(R2=0.87),MPA-AUC0-12 h=5.35+0.87 C1.5+1.22 C2.0+9.85 C8.0(R2=0.90),MPA-AUC0-12 h=4.16+0.98 C1.5+1.17 C2.0+1.03 C4.0+7.74 C8.0(R2=0.93).Conclusion The multivariate regression model with 3 sampling points is a good predictor of MPA-AUC0-12 h.This model can be used to evaluate the MPA-AUC of heart transplantation recipients. |
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| Keywords: | mycophenolic acid pharmacokinetics limited sampling strategy heart transplantation therapeutic drug monitoring |
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