Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers

Authors:	Christian Funck-Brentano Jean Szymezak Olivier Steichen Dominique Ducint Mathieu Molimard Véronique Remones Michel Azizi Pascale Gaussem

Affiliation:	1. Inserm, CIC-9304 and UMRS-956, Paris, France;2. AP–HP, Pitié-Salpêtrière Hospital, Department of Pharmacology and CIC-9304, Paris, France;3. UPMC Univ Paris 06, Faculty of Medicine, Department of Pharmacology and UMRS-956, Paris, France;4. AP–HP, hôpital européen Georges-Pompidou, service d’hématologie biologique, Paris, France;5. Inserm, CIC-9201, Paris, France;6. CHU de Bordeaux, laboratoire de pharmacologie, Bordeaux, France;7. University de Bordeaux, U657, Bordeaux, France;8. AP–HP, hôpital européen Georges-Pompidou, CIC-9201, Paris, France;9. Université Paris Descartes, Sorbonne Paris Cité, Department of Hypertension and Vascular Medicine, Paris, France;10. Université Paris Descartes, Sorbonne Paris Cité, Department of Haematology, Paris, France;11. Inserm, UMRS-765, faculté de pharmacie, Paris, France

Abstract:

Keywords:	Clopidogrel CYP2C19 protein Drug interactions Proton-pump inhibitors Vasodilator-stimulated phosphoprotein Clopidogrel CYP2C19 Interactions médicamenteuses Inhibiteurs de pompes à protons Protéine VASP ADP" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" adenosine diphosphate CYP" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" cytochrome P-450 EM" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" extensive metabolizer IPA" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" inhibition of platelet aggregation MFI" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" mean fluorescence intensity MPA" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" maximal platelet aggregation PGE1" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" prostaglandin E1 PPI" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" proton-pump inhibitors PRI" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" platelet reactivity index VASP" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" vasodilator-stimulated phosphoprotein
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