中草药东风菜水和醇提取物的镇痛作用研究

目的对中草药东风菜水和醇2种提取物的镇痛效果进行评价。方法采用水和75%乙醇2种溶剂分别对东风菜药材进行提取,通过冰醋酸致小鼠扭体实验、热板致小鼠足痛实验观察东风菜水和醇2种提取物的镇痛作用。结果与生理盐水组比较,东风菜2种提取物高(7.2 g/kg)、低(3.6 g/kg)剂量组对冰醋酸致小鼠扭体和热板致小鼠足痛有明显的抑制作用(P<0.01,P<0.05),且存在量效关系。结论东风菜具有较好的镇痛作用,其水提物的镇痛效果优于醇提物。

Research on the Analgesic Effect of Water and Alcohol Extract of Chinese Herbal Medicine Scabrous Doellingeria Rhizome and Root

Objective To evaluate the analgesic effects of two extracts of water and alcohol of Scabrous Doellingeria Rhizome and Root,a Chinese herbal medicine.Methods Two solvents of water and 75%ethanol were used to extract the medicinal materials of Scabrous Doellingeria Rhizome and Root respectively,and the analgesic effects of the two extracts of Scabrous Doellingeria Rhizome and Root water and alcohol were observed through the glacial acetic acid-induced writhing experiment in mice and the hot plate-induced mouse foot pain experiment effect.Results Compared with the normal saline group,the high-dose(7.2g/kg)and low-dose(3.6g/kg)doses of the two extracts of Scabrous Doellingeria Rhizome and Root had significant effects on glacial acetic acid-induced writhing in mice and hot plate-induced foot pain in mice.Inhibition(P<0.01,P<0.05),and there is a dose-effect relationship.Conclusion Scabrous Doellingeria Rhizome and Root has a good analgesic effect,and the analgesic effect of its water extract is better than that of alcohol extract.