归脾汤治疗不寐合并焦虑抑郁临床观察

目的对不寐合并焦虑抑郁患者采用归脾汤加减治疗的效果进行观察。方法选取2018年1月—2019年1月收治的132例不寐合并焦虑抑郁患者,随机分为观察组与对照组,各66例。对照组给予常规西药治疗,观察组在西药治疗的基础上联合归脾汤加减治疗,对2组治疗效果进行对比。结果治疗后1、2、4周,2组患者匹兹堡睡眠质量指数(PSQI)评分均低于治疗前(P<0.05),且观察组治疗后各时间段PSQI评分均低于对照组,差异有统计学意义(P<0.05);治疗后,2组焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分均低于治疗前(P<0.05),且观察组SAS、SDS评分均低于对照组,差异有统计学意义(P<0.05);2组均未出现严重不良反应,2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对不寐合并焦虑抑郁患者采用归脾汤加减治疗,对患者睡眠质量有明显提高,同时对患者焦虑、抑郁等不良情志状态有显著改善作用,且用药安全性较高,值得推广应用。

Clinical Observation on Guipi Decoction in the Treatment of Insomnia with Anxiety and Depression

Objective To observe the effect of Guipi Decoction on patients with and without anxiety and anxiety and depression.Methods A total of 132 patients with insomnia combined with anxiety and depression who were treated between January 2018 and January 2019 were randomly divided into observation group and control group,each with 66 cases.The control group was treated with conventional western medicine,and the observation group was treated with western medicine.Based on the combined treatment of Guipi decoction,the treatment effects of the two groups were compared.Results At 1 week,2 weeks,and 4 weeks after treatment,the PSQI scores of the two groups were lower than those before treatment(P<0.05),and the PSQI scores of the observation group were lower than those of the control group at each time period after treatment(P<0.05).After treatment,the SAS score and SDS score of the two groups were lower than before treatment(P<0.05),and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Adverse drug reactions were compared,and there were no serious adverse reactions in the two groups,and the difference was not statistically significant(P>0.05).Conclusion The use of Guipi decoction in patients with insomnia combined with anxiety and depression can significantly improve the sleep quality of patients,meanwhile,it can significantly improve the anxiety,depression and other adverse emotional states of patients.It is worthy of promotion and application.