| 吗啡对吗啡依赖大鼠腹侧苍白球神经元放电的影响 |
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| 引用本文： | 贺世明,高国栋,胡三觉,邢俊玲,王学廉,赵振伟. 吗啡对吗啡依赖大鼠腹侧苍白球神经元放电的影响[J]. 中国药物依赖性杂志, 2005, 14(1): 20-23 |
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| 作者姓名： | 贺世明 高国栋 胡三觉 邢俊玲 王学廉 赵振伟 |
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| 作者单位： | 1. 第四军医大学唐都医院神经外科,西安,710038
2. 第四军医大学神经科学研究所,西安,710032 |
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| 摘 要： | 目的 :研究吗啡对吗啡依赖大鼠腹侧苍白球的电生理影响 ,探讨其在成瘾机制中的作用。方法 :通过单细胞细胞外记录吗啡依赖大鼠腹侧苍白球的电信号 ,观察吗啡对放电的影响。结果 :吗啡依赖大鼠腹侧苍白球神经元放电频率给药前为 3 76Hz±s 1 18Hz,注射吗啡后为 13 2 2Hz±s 2 37Hz;并且纳洛酮可以逆转这种兴奋效应。结论 :吗啡显著兴奋吗啡依赖大鼠腹侧苍白球神经元 ,腹侧苍白球在药物强化过程中起着重要作用。
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| 关 键 词： | 腹侧苍白球 成瘾 吗啡 电生理 大鼠 |
| 修稿时间： | 2004-05-17 |
EFFECTS OF MORPHINE ON ELECTROPHYSIOLOGICAL DISCHARGE IN VENTRAL PALLIDAL NEURONS OF MORPHINE DEPENDENT RATS |
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| HE Shiming,GAO Guodong,HU Sanjue,XING Junling,WANG Xuelian ,ZHAO Zhenwei. EFFECTS OF MORPHINE ON ELECTROPHYSIOLOGICAL DISCHARGE IN VENTRAL PALLIDAL NEURONS OF MORPHINE DEPENDENT RATS[J]. Chinese Journal of Drug Dependence, 2005, 14(1): 20-23 |
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| Authors: | HE Shiming GAO Guodong HU Sanjue XING Junling WANG Xuelian ZHAO Zhenwei |
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| Affiliation: | HE Shiming1,GAO Guodong1,HU Sanjue2,XING Junling2,WANG Xuelian 1,ZHAO Zhenwei1 1 |
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| Abstract: | Objective: To study the electroph ys iological properties of ventral pallidal neurons of rat with morphine dependence so as to understand the idiographic effect of ventral pallidum in the mechanism o f addiction. Methods:The firing of ventral pallidal neurons in the action of morphine and naloxone was recorded and analyzed in the morphine dependent rats with extracellular single-unit recording. Results :The frequency of firing was 3.76 Hz±s 1.18 Hz on ventral pallidal n eurons in the morphine dependent rats and 13.22 Hz±s 2.37 Hz after morphi ne injected. The effect of morphine was reversed by naloxone. Conclusi on:The firing of ventral pallidal neurons is excited prominently from morphine in the morphine dependent rats. Ventral pallidum has an important role in drug reward. |
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| Keywords: | ventral pallidum morphine dependence morphine electrophysiology rats |
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