兔视神经间接损伤病理学观察

目的　观察视神经间接损伤后病理学过程。方法　选用７２ 只兔（１４４ 只眼）制作视神经间接损伤动物模型,随机分为单纯致伤组和激素治疗组。动态行光镜和电镜观察,采用计算机行轴突计数。结果　视神经间接损伤后主要表现为水肿、髓鞘脱失、髓鞘再生和轴突的改变。激素治疗组的水肿较轻（Ｐ＜０－０１）,有髓纤维计数较多。结论　视神经发生间接损伤后主要改变是神经的水肿、脱髓鞘和轴突的变化。激素有一定的治疗作用。

A pathological study on indirect optic nerve injury in rabbit eyes

Objective To study the pathological changes after indirect optic nerve injury Methods Animal models (72 rabbits, 144 eyes) for intracanalicular optic nerve injury was developed by keeping the optic canal intact The pathological changes of optic nerve were observed under light microscope and transmission electron microscope and the number of myelinated axons was enumerated by computer aided image analyzer The data were analyzed by using variance of SAS software Results The model contributed much valuable information regarding nerve edema, loss of myelin, myelin regeneration and changes of axons The edematous area in the optic nerve injury was reduced ( P <0 01) by treating with prednisone The counted number of myelinated fibers showed more in the group treated by prednisone than that in the group without treatment Conclusions Significant changes of optic nerve after indirect injury are edema, demyelination and the change of axon amount The effects of prednisone on reducing these pathological changes are demonstrated in this study