| 苄丙咯、尼莫地平和尼卡地平对小鼠脑钙调蛋白依赖性蛋白激酶Ⅱ活力的影响 |
| |
| 引用本文： | 唐放鸣,张光毅.苄丙咯、尼莫地平和尼卡地平对小鼠脑钙调蛋白依赖性蛋白激酶Ⅱ活力的影响[J].中国药理学通报,1992(5). |
| |
| 作者姓名： | 唐放鸣 张光毅 |
| |
| 作者单位： | 徐州医学院生化教研室 徐州221002
(唐放鸣)，徐州医学院生化教研室 徐州221002(张光毅) |
| |
| 基金项目： | 国家自然科学基金资助课题 |
| |
| 摘 要： | 体外实验发现,苄丙咯(bepridil.Bep)能显著抑制提纯的鼠脑钙调蛋白依赖性蛋白激酶(CaM—PKⅠ)的活力,其半抑制浓度约为0.3mmol·L~(-1),而尼莫地平(nimodinine,Nim)和尼卡地平(nicardipine;Nic)对该酶活力均无明显影响。实验结果表明,Bep对CaM—PKⅡ的抑制是通过擂抗CaM而实现的。
|
| 关 键 词： | 苄丙咯 尼莫地平 尼卡地平 钙调蛋白依赖性蛋白激酶 |
Effects of bepridil,nimodipine and nicardipine on the activity of CaM dependent protein kinase Ⅱ from mouse cerebrum in vitro |
| |
| TANG Fang -Ming,ZHANG Guang-Yi.Effects of bepridil,nimodipine and nicardipine on the activity of CaM dependent protein kinase Ⅱ from mouse cerebrum in vitro[J].Chinese Pharmacological Bulletin,1992(5). |
| |
| Authors: | TANG Fang -Ming ZHANG Guang-Yi |
| |
| Abstract: | The effects of bepridil, ni-modipine and nicardipine on the activity of CaM - dependent protein kinase Ⅱ from mouse cerebrum were studied in vitro. Tt was found that bepridil significantly inhibitied the activity of CaM - PK Ⅱ with an IC50 value of 0. 3 mmol · L-1. but nimodipine and nicardipine did not basi-
cally influence the activity of the enzyme. The experimental results showed that the inhibitory effect of bepridil on the activity of CaM - PK Ⅱ was an antagonistic action of bepridil to CaM. |
| |
| Keywords: | bepridil: nimodipine nicardipine CaM -dependent protein ki-naseⅡ |
| 本文献已被 CNKI 等数据库收录！ |
