13C-尿素呼气试验诊断幽门螺杆菌的临床应用

应用13C-尿素呼气试验(13C-UBT)评估胃镜常规检查幽门螺杆菌(HP)显示为阴性的患者的HP感染情况及根除HP的治疗效果。选择胃镜组织检查及快速尿素酶试验HP阴性的胃肠道疾病患者,以非胃肠道疾病患者为对照组,行13C-UBT检测。对13C-UBT检测HP阳性病例施行根除治疗,治疗后行13C-UBT复查,作为评价疗效指标。结果640例胃镜常规检查HP阴性的患者中,有389例13C-UBT结果为HP阳性,阳性率60.8%。对13C-UBT检测HP阳性病例分别施行PPI三联、PPI二联、单纯PPI治疗,其转阴率分别为83.8%,18.4%,3.3%。三种治疗方案之间有显著性差异(P<0.05)。对于胃镜常规检查显示HP阴性的病例中,应用13C-UBT有助于提高检出率和疗效判断。

Application of 13C-urea Breath Test in Patients Diagnosed as H. pylori-negative by Gastroscopy

~(13)C-urea breath test(()~(13)C-UBT)was used to evaluate infection rate of(H.pylori)(HP) and effect of HP eradication in patients diagnosed as HP-negative by histology and rapid urease test.Patiens without gastrointestinal disorders were set as control group.Within 640 patients diagnosed as HP-negative by histology and rapid urease test,there were 389 patients showed HP-positive by()~(13)C-UBT.The positive rate of HP was 60.8%.389 patients diagnosed as HP-positive by()~(13)C-UBT were treated with PPI-based triple therapy,PPI-based double therapy and single PPI therapy,respectively.After treatment,the negative rate of()~(13)C-UBT was 83.8%,18.4% and 3.3%,respectively.The results showed significant difference between three kinds of therapy(P<0.05).Therefore,()~(13)C-UBT could improve the diagnostic rate of HP to patients who diagnosed as HP-negative by histology and rapid urease test.