| 曲唑酮对脑卒中后抑郁症患者认知功能的影响 |
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| 引用本文： | 周刚,韩伯军,张剑宇,盛蕾.曲唑酮对脑卒中后抑郁症患者认知功能的影响[J].苏州大学学报(自然科学版),2001,21(5):543-544. |
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| 作者姓名： | 周刚 韩伯军 张剑宇 盛蕾 |
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| 作者单位： | 周刚（东南大学医学院附属江阴医院神经内科,江苏江阴,214400）
韩伯军（东南大学医学院附属江阴医院神经内科,江苏江阴,214400）
张剑宇（东南大学医学院附属江阴医院神经内科,江苏江阴,214400）
盛蕾（东南大学医学院附属江阴医院神经内科,江苏江阴,214400） |
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| 摘 要： | 目的探讨曲唑酮对脑卒中后抑郁症患者认知功能的影响.方法将脑卒中后抑郁症患者52例随机分为曲唑酮治疗组(n=28)和对照组(n=24),治疗前、治疗后4周及6周分别子HAMD评分和MMSE评分.结果治疗4周及6周后,治疗组抑郁症状改善者明显高于对照组(P＜0.05),且在曲唑酮治疗组,患者的MMSE评分较对照组显著提高(P＜0.05).结论曲唑酮可通过改善脑卒中后抑郁症患者的抑郁状态有效提高其认知功能.
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| 关 键 词： | 脑卒中 抑郁症 认知功能 曲唑酮 |
| 文章编号： | 1000-5749(2001)05-0543-02 |
| 修稿时间： | 2001年4月27日 |
Effect of Trazodone on Cognitive Impairment after Poststroke Depression |
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| ZHOU Gang,HAN Bo-jun,ZHANG Jian-yu,et al.Effect of Trazodone on Cognitive Impairment after Poststroke Depression[J].Suzhou University Journal of Medical Science,2001,21(5):543-544. |
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| Authors: | ZHOU Gang HAN Bo-jun ZHANG Jian-yu |
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| Abstract: | Objective To investigate the effects of trazodone on cognitive impairment after poststroke depression.Methods Patients with poststroke depression ( n =52)participated in our treatment study with trazodone or placebo randomly. Change in depression mood was measured with the Hamilton Rating Scale for Depression(HAME) and cognitive impairment was assessed with thd Mini-Mental State Examination(MMSE) before treatment,4 weeks and 6 weeks after treatment.Results Patients who received traxzodone hadsignificantly had greater recovery both in depressive mood and cognitive function.Conclusion Trazodone can promote cognitive recovery in victims of stroke byimproving their depressive moods. |
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| Keywords: | Cerebrovascular disorders depression trazodone |
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