肺透明细胞瘤临床病理学观察

目的探讨肺透明细胞瘤的临床病理学和免疫组化表型特点、组织起源及鉴别诊断。方法对1例肺透明细胞瘤运用光镜、HE及免疫组化方法分析,并复习相关文献。结果肺透明细胞瘤瘤细胞圆形或椭圆形,胞界清楚,胞浆透明或嗜伊红,无明显核分裂像。免疫组化:HMB-45(+)、CD34(+)、CK(-)、EMA(-)、S-100(-)、Syn(-)、CgA(-),组织化学PAS(+)。结论肺透明细胞瘤是一种较罕见的肿瘤,大多呈良性,坏死罕见,若有坏死,需考虑恶性可能,治疗通常为手术切除。其诊断和鉴别诊断主要依靠组织病理学及免疫组化,熟悉其形态学有利于与其它类似病变如转移的肾透明细胞癌及肺自身发生的透明细胞癌等鉴别。

Clinicopathologic Observation on Clear Cell Tumor of Lung

Objective To study the clinicopathological and immunohistochemical characteristics,origin of tissue and differential diagnosis of clear cell tumor of lung.Method A case of clear cell tumor of lung was investigated by means of light microsopy,HE stain and immunohistochemistry.The related literature was reviewed.Results The tumor was composed of round or oval cells with distinct cell borders and abundant clear or eosinophilic cytoplasm.No obvious mitosis was found.Immunohistochemical stain showed positive for HMB-45 and CD_(34),negative for CK,EMA,S-100,Syn and CgA.Histochemical stain showed positive for PAS.Conclusions Clear cell tumor of lung is a kind of rare neoplasm,most of which is benign.The presence of necrosis is extremely rare and should lead to the consideration of malignancy.The usual treatment is operation.Its diagnosis mainly relies on histopathological and immunohistochemical fingdings.Being familiar with its morphologic features is helpful to distinguish it from other similar lesions,such as metastatic renal cell carcinoma,clear cell carcinoma of lung,etc.