| 细胞凋亡抑制基因bcl-2在血管瘤发病中作用的研究 |
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| 引用本文： | 程立新,梁杰,汤少明.细胞凋亡抑制基因bcl-2在血管瘤发病中作用的研究[J].中华整形外科杂志,1999,15(1). |
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| 作者姓名： | 程立新 梁杰 汤少明 |
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| 作者单位： | 广东医学院整形外科研究所 |
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| 摘 要： | 目的阐明细胞凋亡抑制基因Ｂ细胞淋巴瘤／白血病２基因（ｂｃｌ２）与血管瘤的关系。方法用免疫组化ＳＰ法检测３８例血管瘤及６例正常皮肤组织中ｂｃｌ２的表达。结果ｂｃｌ２在海绵状及蔓状血管瘤中表达高于正常；毛细血管瘤中表达低于正常；其间的差异有统计学意义。结论从以上结果可以认为：海绵状及蔓状血管瘤增生与ｂｃｌ２表达增高有关；而ｂｃｌ２在毛细血管瘤中表达低说明其存在自然消退的可能。
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| 关 键 词： | 血管瘤 B细胞淋巴瘤／白血病-2基因 免疫组化 |
The study on the role of apoptosis suppressive gene bcl2 in the pathogenesis of
hemangioma |
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| CHENG Lixin,LIANG Jie,TANG Shaoming,et al..The study on the role of apoptosis suppressive gene bcl2 in the pathogenesis of
hemangioma[J].Chinese Journal of Plastic Surgery,1999,15(1). |
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| Authors: | CHENG Lixin LIANG Jie TANG Shaoming |
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| Institution: | CHENG Lixin,LIANG Jie,TANG Shaoming,et al.The Institute of Plastic
Surgery,Guangdon Medical College,Guangzhou 524023 |
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| Abstract: | Objective\ To elucidate the
relationship between bcl2 and hemangioma. Methods\ We investigated the expression of bcl2
in 38 samples of hemangioma (19 cases of capillary hemangioma,10 cases of cavernous
hemangioma,9 cases of racemose hemangioma) and 6 samples of normal skin by
immunohistochemical SP method. Results\ The results showed that the expression of bcl2 was
higher in cavernous and racemose hemangioma than in the controls,the expression of bcl2 was
lower in capillary hemangioma than in the controls.The differences were statistically significant.
Conclusion\ It can be deduced from the results that there is an intimate relationship between
bcl2 and the growth of cavernous and racemose hemangioma,and the lower expression of bcl2
in capillary hemangioma shows that capillary hemangioma may disappear naturally. |
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| Keywords: | Hemangioma bcl2Immunohistochemistry |
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