| 沙土鼠急性脑缺血／再灌注期间脑内自由基代谢水平的变化 |
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| 引用本文： | 王国贤,刘丹平.沙土鼠急性脑缺血／再灌注期间脑内自由基代谢水平的变化[J].辽宁医学院学报,1995,16(3):4-6. |
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| 作者姓名： | 王国贤 刘丹平 |
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| 摘 要： | 本实验采用沙土鼠双侧颈总动脉结扎模型观察急性脑缺血／再灌注期间脑内自由基代谢水平的变化。结果发现缺血４０ｍｉｎ时丙二醛（ＭＤＡ）含量明显增加，超氧化物歧化酶（ＳＯＤ）活性显著下降，谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性略有降低；再灌注１ｈ后ＭＤＡ含量进一步增加，ＳＯＤ活性进一步下降，ＧＳＨ－Ｐｘ活性也明显降低，结果表明脑缺血／再灌注期间脑内出自由基代谢紊乱。
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| 关 键 词： | 脑缺血 再灌注损伤 自由基 |
ALTERATIONS OF FREERADICALMETABOLIC LEVELS INBRAIN TISSUE OF GERBILSDURING ACUTE CEREBRALISCHEMIA/REPERFUSION |
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| Wang Guoxian,Xiao Zhijie.ALTERATIONS OF FREERADICALMETABOLIC LEVELS INBRAIN TISSUE OF GERBILSDURING ACUTE CEREBRALISCHEMIA/REPERFUSION[J].Journal of Liaoning Medical University (LNMU) Bimonthly,1995,16(3):4-6. |
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| Authors: | Wang Guoxian Xiao Zhijie |
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| Institution: | Wang Guoxian;Xiao Zhijie(Department of pharmacology; Jinzhou Medical College)Liu Danping(The First Affiliated Hospital Jinzhou Medical College) |
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| Abstract: | Free radical metabolic levels were observed in acute ischemia/reperfusion brain tissue induced by bilateral ligation of common carotid arteries of gerbils.It was found that after ischemia occurred for 40 minutes the content of malondiadehyde(MDA)significantly increased; the activity of superoxidte dismutase(SOD)evidently decreased: glu tathione peroxidase(GSH-Px)slightly decreased. After one-hour reperfusion the content of MDA further increased; the activity of SOD further decreased; the activity of GSH-Px significantly decreased too These results indicate that free radical metabolism in brain tissue becomes disordered during cerebral ischemia/reperfusion. |
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| Keywords: | gerbiljcerebral ischemia/reperfusion free radical |
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