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| 川芎油自乳化释药系统体外评价 | |
| 引用本文： | 蔡勤,梁隆,黄艳萍,侯世祥. 川芎油自乳化释药系统体外评价[J]. 中国中药杂志, 2007, 32(19): 2003-2007 |
| 作者姓名： | 蔡勤 梁隆 黄艳萍 侯世祥 |
| 作者单位： | 1. 四川大学,华西药学院博士后流动站,四川,成都,610041;四川科伦实业集团,四川,成都,610500 2. 四川科伦实业集团,四川,成都,610500 3. 四川大学,华西药学院,四川,成都,610041 |
| 基金项目： | 国家博士后科研工作站四川科伦实业集团有限公司博士后在研项目 |
| 摘 要： | 目的：探讨川芎油自乳化释药系统(VOC SEDDS)体外评价方法。方法：通过研究VOC SEDDS自乳化效率、成乳后乳剂性质和体外溶出行为对VOC SEDDS进行体外评价。结果：优选出的自乳化处方5 min内已基本乳化完全,乳化后乳滴的平均粒径为102 nm左右,ζ电位均在-30 mV左右,离心稳定性良好；成乳后得到O/W型乳剂；处方重现性高；以藁本内酯为指标,体外溶出结果表明30 min内药物的体外溶出可达80％；光照和高温条件下稳定性良好。结论：VOC SEDDS自乳化能力强,稳定性好,体外溶出率高。 |
| 关 键 词： | 川芎油 自乳化释药系统 体外评价 |
| 文章编号： | 1001-5302（2007）19-2003-04 |
| 收稿时间： | 2007-01-08 |
| 修稿时间： | 2007-01-08 |
Volatile oil from Rhizome of Ligusticum Chuanxiong; Self-emulsifying drug delivery system; In vitro evaluation |
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| CAI Qin;; LIANG Long; HUANG Yan-ping; HOU Shi-xiang. Volatile oil from Rhizome of Ligusticum Chuanxiong; Self-emulsifying drug delivery system; In vitro evaluation[J]. China Journal of Chinese Materia Medica, 2007, 32(19): 2003-2007 | |
| Authors: | CAI Qin LIANG Long HUANG Yan-ping HOU Shi-xiang |
| Affiliation: | 1. Postdoctor Mobile Station, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; 2. Sichuan Kelun Industrial Group CO LTD, Chengdu 610500, China; 3. West China School of Pharmacy., Sichuan University, Chengdu 610041, China |
| Abstract: | Objective: To investigate the evaluation method for self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong (VOC SEDDS). Method: The self-emulsifying ability, the efficiency of self-emulsification, the properties of emulsion, the dissolution of volatile oil from Rhizome of Ligusticum Chuanxiong and the stability of the emulsion were determined. Result: The optimized formulation can fully emulsify in 5 min and the particle sizes were around 102 nm. Zeta potential was about -30 mV. The O/W emulsions were stable through centrifugation with high reproducibility. In vitro dissolution test indicated that over 80% of drug dissolved in 30 min and VOC SEDDS was stable under light and high temperature in 10 d. Conclusion: VOC SEDDS has strong self-emulsifying ability, fine stability and high dissolution rate in vitro. |
| Keywords: | Volatile oil from Rhizome of Ligusticum Chuanxiong Self-emulsifying drug delivery system In vitro evaluation |
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