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| 细胞角蛋白和波形蛋白在皮肤淀粉样变淀粉样蛋白中表达的研究 | |
| 引用本文： | 杨敏,杨丽,李邻峰,常建民.细胞角蛋白和波形蛋白在皮肤淀粉样变淀粉样蛋白中表达的研究[J].临床皮肤科杂志,2010,39(4). |
| 作者姓名： | 杨敏 杨丽 李邻峰 常建民 |
| 作者单位： | 1. 卫生部北京医院皮肤科,北京,100730 2. 卫生部北京医院病理科,北京,100730 3. 北京大学第三医院皮肤科,北京,100083 |
| 摘 要： | 目的:探讨皮肤淀粉样变淀粉样蛋白的生物学来源.方法:应用免疫组化染色技术检测4种角蛋白(cytokeratins,CKs)及波形蛋白在20例斑状或苔藓样型皮肤淀粉样变淀粉样蛋白中的表达情况.结果:①CK3413E12和CK5/6在20例标本的淀粉样蛋白团块中均呈阳性表达:而AE1/AE3、CK10/13和波形蛋白在淀粉样蛋白团块中均呈阴性表达;②淀粉样蛋白团块中波形蛋白表达阳性的成纤维细胞明显增生.结论:淀粉样蛋白主要来源于凋亡的表皮基底细胞而非真皮组织. |
| 关 键 词： | 淀粉样变 皮肤 淀粉样蛋白 角蛋白 波形蛋白 免疫组化 |
Cytokeratins and vimentin expressions in the amyioids of Hchen amyloidosis and macular amyloidosis |
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| YANG Min,YANG Li,LI Lin-feng,CHANG Jian-min.Cytokeratins and vimentin expressions in the amyioids of Hchen amyloidosis and macular amyloidosis[J].Journal of Clinical Dermatology,2010,39(4). | |
| Authors: | YANG Min YANG Li LI Lin-feng CHANG Jian-min |
| Abstract: | Objective:To discuss the biological origin of the arnyloids in macular amyloidosis(MA)and lichen amyloidosis(LA).Methods:The immunohistochemieal staining was used to investigate the expressions of cytokeratins(CKs)and vimentin in amyloid deposits of formalin-fixed and paraffin-embedded tissue specimens from 13 patients with LA and 7 with MA.Results:In amyloid deposits,only CK34βE12 and CK5/6 was positive in 20 biopsy specimens,and AE1/AE3,CK10/13 and vimentin were negative.Fibroblast cells which could express vimentin presented significant proliferation among the amyloids.Conclusion:The results confirm the hypothesis that the amyloid in lichen and macnlar amyloidosis mainly derived from basal keratinocytes,not from dermal tissues. |
| Keywords: | amyloidosis cutaneous amyloid eytokeratin vimentin immunohistochemistry |
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