小细胞肺癌的组织学亚型与疗效和生存关系的探讨

 54例小细胞肺癌的组织学亚型根据1977年WHO分类,燕麦细胞型42例,中间细胞型癌7例,混合燕麦细胞癌型5例,所有病例接受同样的联合化疗,用或不用放疗,燕麦细胞癌有效率(CR⁺PR)69%,中间细胞癌型⁺混合细胞癌型有效率(PR)50%。燕麦细胞癌的有效率与中间细胞型⁺混合细胞型有效率相比有显著差异P<0.01。获得完全缓解的15例燕麦细胞癌中6例长期无病生存3～10年,仅1例是混合细胞型生存29个月。

RELATIONSHIP BETWEEN RESPONSE TO THERAPY AND SURVIVAL AND HISTOLOGIC SUBTYPE IN SMALL CELL CARCINOMA OF THE LUNG

According to WHO classification. 54 cases of small cell carcinoma of thelung were hiatological subbtyped. of these, oat cell type 42 cases, intermediate celt sutype 7 cases, 5 cases of combined oat cell subtype. All the 54 cases were treatcd with the same Combinedion chemtherapy with or Mithout radiotherapy, for oat cell carcinoma, complete and partial response was 69%. for intermediate subtype and snixed cell subtype, only 50% had partial response. compared with intermediate cell and combined oat cell, oat cell carcanoma responce was sign ificantly higher (P1.01). 15 cases of oat cell carcinoma were observed with complete response, among them 6 cases were found to be long-term disease free for 3-10 years. on the fther bend, only one case observed of intermedate tand mixed cell subtype sureived 29 months For subtype oat cell carcinoma, the median survival rate was significantly higher than subtgpe intermediate and mixed oat cell carcinoma(12months SV 5 months, p0.01)