| 加味四妙散治疗多发性肌炎湿热证的实验研究 |
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| 引用本文： | 赖名慧,刘友章,符路娣.加味四妙散治疗多发性肌炎湿热证的实验研究[J].中华中医药杂志,2009(7). |
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| 作者姓名： | 赖名慧 刘友章 符路娣 |
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| 作者单位： | 南方医科大学;广州中医药大学第一附属医院;广州中医药大学; |
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| 基金项目： | 广东省科技计划项目(No.2008B060600065) |
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| 摘 要： | 目的:观察加味四妙散对实验性多发性肌炎湿热证型的作用机制及疗效。方法:采用免疫注射与湿热证造模的方法相结合,制作成豚鼠多发性肌炎湿热证模型,并应用肌电图、血清肌酶谱、病理、电镜检测等手段,应用加味四妙散和泼尼松等药物治疗,进行分组干预对比其疗效。结果:治疗后的肌电图,以中药高剂量组的平均时限、波幅改善程度更优于西药泼尼松组;各治疗组豚鼠血清肌酸磷酸激酶(CPK)、乳酸脱氢酶(LDH)、谷草转氨酶(AST)得到不同程度的控制,以中西药组能更好的控制血清肌酶的升高;而在肌肉及肝组织病理、超微结构改变,中药高剂量组较泼尼松组改善显著;间质性肺炎情况的改善程度则以中西药组疗效最好。结论:加味四妙散对实验性多发性肌炎湿热证型有良好的治疗作用,对细胞免疫反应有显著的抑制作用,控制了炎性细胞浸润,这可能是参与机体整体免疫状态的调节有关。
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| 关 键 词： | 多发性肌炎 加味四妙散 湿热证 实验研究 |
Experimental study on Modified Simiao Powder in treating polymyositis with damp-heat syndrome |
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| LAI Ming-hui,LIU You-zhang,FU Lu-di.Experimental study on Modified Simiao Powder in treating polymyositis with damp-heat syndrome[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(7). |
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| Authors: | LAI Ming-hui LIU You-zhang FU Lu-di |
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| Institution: | LAI Ming-hui1,LIU You-zhang2,FU Lu-di3(1Southern Medical University,Guangzhou 510515,China,2The First Hospital Affiliated to Guangzhou University of TCM,Guangzhou 510405,3Guangzhou University of TCM,China) |
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| Abstract: | Objective:To observe the mechanism and effect of Modified Simiao Powder on experimental polymyositis with damp-heat syndrome.Methods:The immunization combined with damp-heat syndrome modeling method was used to set up damp-heat model of polymyositis in guinea pigs.Methods of pathology,electron microscopy,electromyography,serum muscle enzymes were used to observe and compare the effects of Modified Simiao Powder and prednisone.Results:After treatment,the average time and improved degree of volatility of EMG ... |
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| Keywords: | Modified Simiao Powder Polymyositis Damp-heat Experimental study |
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